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Clinical Trials/NCT07304479
NCT07304479
Recruiting
Not Applicable

Effects of Sevoflurane Versus Desflurane Anesthesia Under Protective Mechanical Ventilation for Robotic Assisted Surgery on Airway Plateau Pressure: a Randomized, Prospective, Blinded Pilot Study

National and Kapodistrian University of Athens1 site in 1 country50 target enrollmentStarted: May 1, 2025Last updated:
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InterventionsSevoflurane (Volatile Anesthetic)Desflurane (volatile anesthetic)

Overview

Phase
Not Applicable
Status
Recruiting
Enrollment
50
Locations
1
Primary Endpoint
airway plateau pressure
OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Overview

Brief Summary

Inhalational anesthetics, when used in abdominal surgery, offer advantages of lung protection and reduced alveolar inflammation. There is little literature, however, in the comparative use of sevoflurane versus desflurane anesthesia in patients undergoing abdominal robotic-assisted surgery and their effects on lung mechanics.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
Triple (Participant, Care Provider, Investigator)

Eligibility Criteria

Ages
18 Years to 87 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Age 18 to 87 years
  • •Undergoing elective robotic-assisted abdominal surgery
  • •ASA physical status I-III

Exclusion Criteria

  • •ASA IV or V
  • •Emergency surgery
  • •Renal insufficiency
  • •Clinically significant respiratory disease
  • •Cardiomyopathy
  • •Uncontrolled hypertension

Arms & Interventions

Sevoflurane (Volatile Anesthetic)

Active Comparator

Intervention: Sevoflurane (Volatile Anesthetic) (Drug)

Deslfurane (Volatile Anesthetic)

Active Comparator

Intervention: Desflurane (volatile anesthetic) (Drug)

Outcomes

Primary Outcomes

airway plateau pressure

Time Frame: Perioperatively

Airway plateau pressure (cmH2O) as displayed on the anesthesia ventilator at the specified time points will be recorded for each participant.

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Aliki Tympa

Assistant Professor of Anesthesiology

National and Kapodistrian University of Athens

Study Sites (1)

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