RhBMP-2 in Intrabony Defects - A Randomized Controlled Trial
- Registration Number
- NCT04368650
- Lead Sponsor
- SVS Institute of Dental Sciences
- Brief Summary
This study evaluated the regenerative potential of rhBMP-2 gel in intrabony defects when compared to sticky bone (control).
- Detailed Description
It was done in 40 subjects who were evaluated for a period of 6 months. the results were evaluated clinically (CAL, PPD) and radiographically (bone fill) and after 6 months.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- Systemically healthy male and female patients age 20-55 years with intrabony defects and probing pocket depth of ≥5mm after initial therapy were included in the study.
Exclusion Criteria
- Medically compromised patients, Subjects who underwent radiotherapy or chemotherapy and smokers were excluded.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Main treatment group BMP-2 The in situ BMP-2 gel was prepared to a concentration of approximately 0.5 μg/ml and were stored at 4oC. The gel was then dispensed at site of interest in the study. Control PRF In patients selected for control group, after degranulation, sticky bone was used to fill the defect. The surgical site was protected and covered using a periodontal dressing.
- Primary Outcome Measures
Name Time Method bone fill 6 months bone fill evaluation done after 6 months by using ImageJ® software
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
SVS Institute of Dental Sciences, Mahabubnagar
🇮🇳Hyderabad, Andhra Pradesh, India