Bone Morphogenetic Protein-2 In Grade II Furcation Defects.

Not Applicable

Completed

• Conditions: Periodontitis
• Interventions: Drug: RhBMP-2 absorbable sponge in grade II furcation; Procedure: PLATELET RICH FIBRIN in grade II furcation

• Registration Number: NCT04372420
• Lead Sponsor: SVS Institute of Dental Sciences

Brief Summary

The present study evaluated clinically and radiographically the regenerative potential of rhBMP-2 in absorbable sponge and PRF in Grade II furcation.

Detailed Description

44 subjects were enrolled in the study. PPD, CAL, plaque index and gingival index were recorded and the evaluation of bone fill was performed after 6 months by using ImageJ® software. After 6 months, the bone fill obtained with rhBMP-2 was higher when compared to PRF. From this trial conducted over a period of 6 months, the unique properties associated with rhBMP-2 in absorbable sponge makes it a potential agent to be used as a graft material for Grade II furcation defects.

Study Timeline

• Study Start: 2017-12-05
• Primary Completion: 2019-09-19
• Study Completion: 2019-10-10
• Status Verified: 2019-12
• Study First Submitted: 2020-04-29
• Study First Submitted QC: 2020-04-29
• Last Update Submitted: 2020-05-02
• Study First Posted: 2020-05-04
• Last Update Posted: 2020-05-05

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 44

Inclusion Criteria

• Systemically healthy male and female patients of age group 20-55 yrs
• grade II furcation involvement and probing pocket depth of ≥5mm

Exclusion Criteria

• Medically compromised patients
• subjects who underwent radiotherapy or chemotherapy in the past 12 months
• patients having uncontrolled periodontal disease and
• subjects smoking ≥10 cigarettes per day were excluded

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RhBMP-2	RhBMP-2 absorbable sponge in grade II furcation	RhBMP-2 belongs to TGF-β super family with osteoinductive property which is capable of promoting bone formation
PLATELET RICH FIBRIN	PLATELET RICH FIBRIN in grade II furcation	Platelet rich fibrin(PRF) is a healing biomaterial with a great potential for bone and soft tissue regeneration, without any inflammatory reactions

Primary Outcome Measures

Name	Time	Method
BONE FILL	6 MONTHS	The evaluation of bone fill was performed after 6 months by using ImageJ® software.

Trial Locations

Locations (1)

RV Chandra; 🇮🇳 Hyderabad, Telangana, India