Measuring Auto-fluorescence of White Corpuscles for the Early Diagnosis and the Monitoring of Pneumonia in ICU
Completed
- Conditions
- Pneumonia
- Registration Number
- NCT02717767
- Lead Sponsor
- Nantes University Hospital
- Brief Summary
The diagnosis of pneumonia is challenging in Intensive Care Unit. The auto-fluorescence of white corpuscles is altered during pneumonia. In presence of bacterial growth on lung samples, the measure of autofluorescence of white corpuscles could help the clinicians to discriminate bacterial colonization from acute infection.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 69
Inclusion Criteria
- Hospitalization in intensive care units
- Mechanical ventilation
- Age > 18 years
- Collection of a lung sample for bacteriological analysis for the suspicion of a first episode of lung infection.
Exclusion Criteria
- Refuse to participate
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pneumonia 28 days Diagnosis of pneumonia (Clinical Pulmonary Infection Score \> 6, with assessment of the chest radiography by a blinded investigator)
- Secondary Outcome Measures
Name Time Method Mortality day 90 Clinical Pulmonary Infection Score > 6 day 3 Intensive Care unit Length of stay day 90 Acute respiratory distress syndrome day 90 PaO2/FiO2 \< 200 with a PEEP \> 5 (Berlin definition)
Duration of mechanical ventilation day 90
Trial Locations
- Locations (4)
Saint-NazaireHospital
🇫🇷Saint-Nazaire, France
Saint-Brieuc Hospital
🇫🇷Saint-Brieuc, France
Blois Hospital
🇫🇷Blois, France
Vannes Hospital
🇫🇷Vannes, France