Inflammatory cytokines in sera and bronchoaleveolar lavage as prognostic marker in children with severe respiratory failure

• Conditions: J96; Respiratory failure, not elsewhere classified

• Registration Number: DRKS00000510
• Lead Sponsor: ZKJ

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-09-16
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Mechanically ventilated children aged >1 month to < 18 years who need bronchoalveolar lavage and blood examination due to medical and theraeuptical reasons. For example, BAL might be needed for microbiological testing and a directed antibiotical therapy. As control group we will include patients who undergo bronchoscopy with bronchoalveolar lavage and blood examination but are not mechanically ventilated. These patients need diagnostic procedures to exclude laryngomalacy and get more information on unexplained tracheal cough.

Exclusion Criteria

Severe concomitant diseases, like congenital lung malformation, immune deficiency or increased cerebral pressure and instability of cardiovascular circulation after manipulation.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Correlation of inflammatory cytokines in BAL and sera with severity of pediatric acute respiratory syndrome (days of ventilation, oxygenation index).

Secondary Outcome Measures

Name	Time	Method
Correlation of inflammatory cytokines in BAL and sera with severity of pediatric acute respiratory -depending of the cause of ARDS