Early Warning Model of Susceptibility and High-risk Population of Cervical Cancer Related to HPV
- Conditions
- Uterine Cervical CancerCervical CancerUterine Cervical Neoplasm
- Registration Number
- NCT04974424
- Lead Sponsor
- Huazhong University of Science and Technology
- Brief Summary
Most uterine cervical high-risk human papillomavirus (HPV) infections are transient, with only a small fraction developing into cervical cancer. Family aggregation studies and heritability estimates suggest a significant inherited genetic component. Candidate gene studies and previous genome-wide association studies (GWASs) report associations between the HLA region and cervical cancer. Adopting a genome-wide approach, we aimed to establish an early warning model for a high-risk population of cervical cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- Female
- Target Recruitment
- 20000
Inclusion Criteria
- (1) Case group a) Aged 25-75 years. b) Han nationality. c) Patients with cervical cancer or cervical precancerous lesions above CIN2 diagnosed by biopsy or postoperative pathological diagnosis.
- (2) Control group: a) Aged 25-75 years. b) Han nationality. c) No family history of cervical cancer or precancerous lesions. d) The results of TCT examination showed no abnormality.
Exclusion Criteria
- (1) suffering from other neoplastic diseases.
- (2) pregnant women.
- (3) those with a history of bone marrow transplantation.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Significant loci of genetic variation 2 The impact of genetic variance on predisposition to cervical cancer
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tongji Hospital
🇨🇳Wuhan, Hubei, China