IRCT2013102715178N1已完成未知
Comparing the efficacy of Tadalafil versus Placebo on pulmonary artery systolic pressure and right ventricular function in patients with beta-thalassemia intermedia
Babol University of Medical Sciences, Research and Technology Assistance0 个研究点目标入组 50 人开始时间: 待定最近更新:
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- no limit 至 no limit（—）
- 性别
- All
入选标准
- •Inclusion criteria (All of the following) : age more than 15 years ; major beta thalassemia patients (significant anemia, Hb< 7 and transfusion dependent) or Intermedia beta thalassemia (milder anemia, Hb between 7 and 10 and usually not transfusion dependent) ; Pulmonary Arterial Hypertension or Right Ventricle Dysfunction. Pulmonary Arterial Hypertension : mean pulmonary arterial pressure more than 25 mmHg at rest or more than 30 mmHg in activity (measured by transthoracic echocardiography). Right ventricular dysfunction as increase in right ventricle end-diastolic dimension (base> 4cm, midpart> 3.5) or decrease in function and ejection fraction of right ventricle according to TAPSE index (lesser than 2cm) and S index (lesser than 11cm) measured by transthoracic echocardiography.
- •Exclusion criteria (One of the following) : age< 15 years ; using nitrates and alpha blockers (except Tamsulosin) at the time of study ; minor beta thalassemia patients
排除标准
- 未提供
研究者
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