The Effect of Pnemoperitoneum on Intracranial Pressure and Cerebral Oxygenation During Laparoscopic Surgery According to Anesthesia Agents: Propofol Based Total Intravenous Anesthesia vs Desflurane Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 主要终点
- the ultrasonographic measurement of optic nerve sheath diameter
研究概览
简要总结
The pneumoperitoneum during laparoscopic surgery have the potential to cause an increase of intracranial pressure (ICP). Previous studies have proposed that ultrasonographic measurements of the optic nerve sheath diameter (ONSD) correlate with signs of increased ICP. The aim of this study is to compare the effect of pnemoperitoneum on intracranial pressure and cerebral oxygenation during laparoscopic surgery according to anesthesia agents, propofol based total intravenous anesthesia (TIVA group) and desflurane anesthesia (Des group).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients (20-80 years of age) scheduled for laparoscopic cholecystectomy undergoing general anesthesia
排除标准
- •Patients with previous history of neurologic disease, carotid disease, transient ischemic attack, ocular disease and ocular surgery
研究组 & 干预措施
TIVA
2% Propofol (Fresofol®), Remifentanil 20mcg/cc (Ultiva®)
干预措施: Propofol (Drug)
Des
Desflurane (Suprane®), Remifentanil continuous infusion (20mcg/cc)
干预措施: Desflurane (Drug)
结局指标
主要结局
the ultrasonographic measurement of optic nerve sheath diameter
时间窗: baseline
optic nerve sheath diameter measured by ultrasonography
次要结局
未报告次要终点