Gastrointestinal pathology in patients with hypogammaglobulinaemia.

Completed

• Conditions: primary immunodeficiency; 10021460

• Registration Number: NL-OMON33548
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 70

Inclusion Criteria

Primary antibodydeficiency:
1. Common Variable Immunodeficiency Syndrome (CVID)
2. X-linked agammaglobulinemia (XLA)
3. IgG subclasse deficiency
4. abnormal vaccinationrespons

Exclusion Criteria

incapable to sign informed consent
Age younger than 18 years.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence and incidence of (pre)malignant and inflammatory pathology in<br /><br>the gastrointestinal tract of patients with a primary antibodydeficiency (CVID,<br /><br>XLA, IgG subclasse deficiency and abnormal vaccinationrespons). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>(1) Prevalence of asymptomatic carrier of bacterial, virale and/or parasitary<br /><br>pathogens.<br /><br>(2) Identification of subgroeps within the group of CVID patients:<br /><br>determination of possible relationship with (B cel) fenotype en genotype (CVID<br /><br>gerelateerde B cel mutaties) and the gastrointestinale pathology. </p><br>