PACTR201611001859416
Completed
N/A
A randomised controlled trial to investigate the efficacy, safety and tolerability of adding a single low primaquine dose to artemether-lumefantrine for the treatment of symptomatic uncomplicated Plasmodium falciparum malaria
niversity of Cape Town0 sites140 target enrollmentNovember 11, 2016
ConditionsMalaria
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Malaria
- Sponsor
- niversity of Cape Town
- Enrollment
- 140
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Plasmodium falciparum positive by RDT
- •Age \> 2 years
- •Weight over 10 kg
- •Prescribed artemether\-lumefantrine according to standard practice
- •Informed consent (by legally acceptable representative if under 18 years of age)
- •Assent in children aged 7 and above
- •Intention to remain in the study area for the duration of the follow\-up period
Exclusion Criteria
- •Evidence of severe illness/ danger signs
- •Known allergy to study medications
- •Medical history of haemolysis, rheumatoid arthritis, lupus erythematosus or cardiac disease
- •In patients receiving concurrently other drugs that are cause hemolysis, bone marrow suppression or QTc interval prolongation
- •Hb \< 7 g/dL
- •A decrease in Hb of \> 2 g/dL between day 0 and day 3 prior to primaquine dose
- •Currently menstruating
- •Pregnant or breastfeeding
- •History of any antimalarials (including primaquine) taken within the last 4 weeks
- •Blood transfusion within the last 90 days
Outcomes
Primary Outcomes
Not specified
Similar Trials
Recruiting
N/A
Reducing disability in older Australians through secondary stroke prevention.ACTRN12611000264987ational Ageing Research Institute (NARI) of Melbourne.300
Completed
N/A
A study to investigate the effect of an ergonomic seat on blood flow in the lower legs.Deep vein thrombosisOther - Research that is not of generic health relevance and not applicable to specific health categories listed aboveACTRN12607000621415ErgoCentric Seating Systems12
Completed
N/A
The effect of a year 9 and 10 high school program, Headstrong, on adolescent depression and mental health literacy.Depression literacyHelp seekingStigmaPsychological distressResilienceSuicidal ideationMental Health - DepressionACTRN12613000823774Professor Helen Christensen1,500
Completed
N/A
The effects of lipid-based multiple micronutrients on the health of children in the developing worldISRCTN73571031Medical Research Council (MRC) (UK)2,250
Completed
N/A
A randomised controlled trial to investigate the effect of regular moderate intensity exercise on plasma fibrinogen in people with type two diabetes: a pilot studyType two diabetesNutritional, Metabolic, EndocrineNon-insulin-dependent diabetes mellitusISRCTN98564438Department of Health80