Genetic Polymorphisms of Interleukin-10 and TNF-α on Outcome of HCV-Related Chronic Liver Disease

Not Applicable

• Conditions: Hepatitis C Virus Infection; Chronic Liver Disease

• Registration Number: NCT00630006
• Lead Sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital

Brief Summary

The prognosis of chronic hepatitis C virus (HCV)infeciton varies from minimal progressive disease to cirrhosis or hepatocellular carcinoma. Host genetic factors contribute to disease severity. It is known that cytokine gene (including tumor necrosis factor-alpha (TNF-alpha) and interleukin-10 (IL-10) polymorphism affect disease prognosis.This study aims to assess the effect of TNF-alpha and IL-10, and their interaction,on prognosis of HCV-related chronic liver disease

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Status Verified: 2007-07
• Study First Submitted: 2008-02-26
• Study First Submitted QC: 2008-03-05
• Last Update Submitted: 2008-03-05
• Study First Posted: 2008-03-06
• Last Update Posted: 2008-03-06
• Study Completion: 2008-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Anti-HCV-positive patients

Exclusion Criteria

• Anti-HCV-negative patients

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: FACTORIAL

Primary Outcome Measures

Name	Time	Method
cytokine gene polymorphism	years

Secondary Outcome Measures

Name	Time	Method
cytokine gene polymorphism on severity of disease	years

Trial Locations

Locations (1)

Kaohsiung Medical University Chung-Ho Memorial Hospital; 🇨🇳 Kaohsiung, Taiwan