Effect of Diet on the Microbiota / Endoccanabinoidome Axis in Response to Physical Activity

Not Applicable

Completed

• Conditions: Activity, Motor; Microbial Colonization; Diet Habit
• Interventions: Other: 3 maximal aerobic tests

• Registration Number: NCT04766528
• Lead Sponsor: Laval University

Brief Summary

Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.

Detailed Description

Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.

Study Timeline

• Study Start: 2019-09-06
• Status Verified: 2019-10
• Primary Completion: 2019-11-14
• Study Completion: 2019-11-14
• Study First Submitted: 2021-02-19
• Study First Submitted QC: 2021-02-19
• Last Update Submitted: 2021-02-19
• Study First Posted: 2021-02-23
• Last Update Posted: 2021-02-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 11

Inclusion Criteria

• women
• 20-30 years old
• healthy
• jogging >1h/week and >3h/week of physical activity
• bmi 18.5-25

Exclusion Criteria

• postmenopausal, pregnancy or lactation
• pathology or medication
• smoking
• more than 7 alcohol consumption/week
• food allergy, food intolerance or food aversion
• important weight change in the last 6 months
• antibiotics in the last 3 months
• night worker
• pathologies

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Canadian diet	3 maximal aerobic tests	The NAM diet had a high content in saturated fatty acids (SFA) and simple sugar and was low in fiber.
Mediterannen diet	3 maximal aerobic tests	The MED diet was abundant in fiber, micronutrients and plant-based proteins. The diet was rich in essential FA like monounsaturated fatty acids (MUFA) and n-3.

Primary Outcome Measures

Name	Time	Method
Endocannabinoid level post physical activity	6 months

Trial Locations

Locations (1)

Institut sur la nutrition et les aliments fonctionnels; 🇨🇦 Québec, Canada