Effect of Dietary Composition on the Gut Microbiota / Endocannabinoidome Axis in Response to Maximal Aerobic Exercise
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Diet Habit
- Sponsor
- Laval University
- Enrollment
- 11
- Locations
- 1
- Primary Endpoint
- Endocannabinoid level post physical activity
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
Both the endocannabinoid system and the microbiome are highly conditioned by nutrition and physical activity, and have an interdependent, bidirectional relationship. We suggest studying the interleaving between the endocannabinoidome-microbiome axis and host metabolism under the combined effect of a diet and physical activity. More specificly, we will study the link between the impact of the diet on the intestinal microbiome and the endocannabinoid reaction after intense exercise.
Detailed Description
Aims of the study are to compare the impacts of two short 7-day contrasted nutritional interventions (the Mediterranean diet (MED) and the Canadian diet (CAN)) on blood metabolites (endocannabinoids) after a maximal aerobic test. A 3 weeks washout between the two diets is planned. Gut microbiome at each test will also be evaluated.
Investigators
Eligibility Criteria
Inclusion Criteria
- •20-30 years old
- •jogging \>1h/week and \>3h/week of physical activity
- •bmi 18.5-25
Exclusion Criteria
- •postmenopausal, pregnancy or lactation
- •pathology or medication
- •more than 7 alcohol consumption/week
- •food allergy, food intolerance or food aversion
- •important weight change in the last 6 months
- •antibiotics in the last 3 months
- •night worker
- •pathologies
Outcomes
Primary Outcomes
Endocannabinoid level post physical activity
Time Frame: 6 months