NCT03738319Unknown不适用
Non-coding RNA in the Exosome of the Epithelia Ovarian Cancer
Lei Li1 个研究点 分布在 1 个国家目标入组 160 人开始时间: 2018年11月10日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Differential expression of miRNA/lncRNA
研究概览
简要总结
This study aims to analyze the expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) by next-generation sequencing in patients with high grade serous ovarian cancer (HGSOC) and benign gynecologic diseases. The candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Confirmed primary high grade serous ovarian cancer
- •Willing to accepted debulking surgeries and adjuvant chemotherapy
- •Good performance status
- •Aged 18 years or older
- •Signed an approved informed consents
排除标准
- •Not meeting all of the inclusion criteria
结局指标
主要结局
Differential expression of miRNA/lncRNA
时间窗: One year
Differential expression of micro-RNA (miRNA) and long non-coding RNA (lncRNA) will be compared between HGSOC group and control group, hence candidate miRNA/lncRNA will be validated as biomarker for the detection and prognosis of HGSOC.
次要结局
- Progression-free survival(Five years)
研究者
Lei Li
Professor
Peking Union Medical College Hospital
研究点 (1)
Loading locations...
相似试验
招募中
1 期
The relationship between non-coding RNA in exosomes and outcomes of thyrotropin receptor antibody (TRAb) of Graves'diseaseGraves' diseaseITMCTR1900002606Department of Endocrinology, Shanghai East Hospital, Tongji University School of Medicine
已完成
不适用
Serum Exosomal Long Noncoding RNAs as Potential Biomarkers for Lung Cancer DiagnosisLung Cancer (Diagnosis)NCT03830619Wuhan Union Hospital, China1,000
尚未招募
不适用
Analysis of exosomal miRNA expression in non-alcoholic fatty liver disease (NAFLD)non-alcoholic fatty liver diseaseJPRN-UMIN000015575Osaka city university200
尚未招募
1 期
Study on the expression profiles of miRNAs-LncRNA in type 2 diabetes-mellitus-mild cognitive impairment with deficiency-excess syndrome of traditional Chinese medicinetype 2 diabetes-mellitus-mild cognitive impairmentITMCTR2000003443Guang'anmen Hospital, China Academy of Chinese Medical Sciences
已完成
2 期
miRNAs, Suicide, and Ketamine - Plasma Exosomal microRNAs as Novel Biomarkers for Suicidality and Treatment OutcomeMajor Depressive DisorderNCT02418195University of Alabama at Birmingham247