The effect of mercury exposure on inflammation in autoimmune disease

Completed

• Conditions: Musculoskeletal Diseases; Systemic Lupus Erythematosus

• Registration Number: ISRCTN31359638
• Lead Sponsor: lster University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-08-04
• Last Update Posted: 24 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Systemic lupus erythematosus (SLE) participants:
1. Aged between 18-65
2. A diagnosis of SLE (American College of Rheumatology criteria)
3. Not currently pregnant
4. Not currently taking any n-3 fatty acid supplements

Control participants:
1. Aged between 18-65
2. Free from illness
3. Not taking any medication (including non-steroidal anti-inflammatories)
4. Not currently pregnant
5. Not currently taking any n-3 fatty acid supplements

Exclusion Criteria

Systemic lupus erythematosus (SLE) participants:
1. Currently on high dose steroids (>10mg daily)
2. Currently suffering from an acute illness
3. Regularly consume more than 3 portions of fish per week
4. Pregnancy
5. Currently taking any n-3 fatty acid supplements

Control participants:
1. Regularly consume more than 3 portions of fish per week
2. Pregnancy
3. Currently taking any n-3 fatty acid supplements

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pro-inflammatory cytokines secreted from peripheral blood mononuclear cells will be measured using a multiplex ELISA assay.

Secondary Outcome Measures

Name	Time	Method
o secondary outcome measures.