Investigating the Role of Brain-derived Neurotrophic Factor (BDNF) Between Pain and Other Neuronal Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 131
- 试验地点
- 1
- 主要终点
- cytokine measurement in cerebrospinal fluid
研究概览
简要总结
Measure the cytokines, transforming or neurotrophic factors in CSF and plasma as the pain markers and as a new therapeutic target for pain control.
详细描述
The research protocol was approved by the Institutional Review Board (IRB) for the Protection of Human Subjects at National Cheng Kung University Hospital (NCKUH/B-ER-104-070). The study procedures were performed according to the rules of IRB and fully explained to the participants. Blood and CSF samples were collected and compared the difference in no pain group, acute pain group, and chronic pain group.
研究设计
- 研究类型
- Observational
- 观察模型
- Ecologic Or Community
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •. Patients undergo spinal anesthesia
- •. Over 20 years of age
- •Patients who are competent to understand the study and provide written informed consent.
排除标准
- •Patients have the contraindication for spinal anesthesia (refuse spinal anesthesia, coagulopathy, severe aortic stenosis)
- •Refuse participated in this study or pre-existent neurological disease.
- •Patients with advanced tumor staging (stage 3 or 4).
结局指标
主要结局
cytokine measurement in cerebrospinal fluid
时间窗: through study completion, an average of 1 year
cytokine measurement ( via ELISA) in cerebrospinal fluid
cytokine measurement in blood
时间窗: through study completion, an average of 1 year
cytokine measurement (via ELISA) in blood
次要结局
未报告次要终点
研究者
Yen Chin Liu
Associate Professor
National Cheng-Kung University Hospital