Relationship Between Oral Lichen Planus and Autoimmune Thyroid Diseases

Recruiting

• Conditions: Oral Lichen Planus

• Registration Number: NCT05403216
• Lead Sponsor: The Dental Hospital of Zhejiang University School of Medicine

Brief Summary

On the basis of previous studies, a validation cohort will be established to explore the relationship between oral lichen planus and autoimmune thyroid diseases, and a disease efficacy prediction strategy can be formed.

Detailed Description

For oral lichen planus patients, the prevalence of Hashimoto's thyroiditis will be investigated and the relationship between levels of anti-TG, anti-TPO antibodies and severity of oral lichen planus will be determined.

Besides, for patients with Hashimoto's thyroiditis, the prevalence of oral lichen planus will be investigated and the relationship between levels of anti-TG, anti-TPO antibodies and severity of oral lichen planus will be determined.

Study Timeline

• Study First Submitted: 2022-03-13
• Study First Submitted QC: 2022-05-30
• Study First Posted: 2022-06-03
• Study Start: 2022-12-01
• Status Verified: 2023-08
• Last Update Submitted: 2023-08-28
• Last Update Posted: 2023-08-31
• Primary Completion: 2024-12-31
• Study Completion: 2024-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• OLP patients without systemic disease

Exclusion Criteria

• OLP patients with severe periodontal disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Level of thyroid function and antibody	1 year	The levels of thyroid hormone and thyroid autoantibodies in serum of OLP patients were detected.
Oral lichen planus (OLP) lesions record	1 year	Record changes of lesions based on the symptoms and signs of the oral lichen planus patient.

Trial Locations

Locations (1)

The Stomatology Hospital, Zhejiang University School of Medicine; 🇨🇳 Hangzhou, Zhejiang, China