Comparing Hyperbaric Levobupivacaine and Hyperbric Ropivacaine as spinal anesthetic drugs for elective lower limb orthopedic surgeries.

Phase 4

Not yet recruiting

Conditions: Medical and Surgical, (2) ICD-10 Condition: M971||Periprosthetic fracture around internal prosthetic knee joint,

Registration Number: CTRI/2023/08/056435

Lead Sponsor: Dr Rajendra Prasad Government Medical college KANGRA at TANDA

Brief Summary: Spinal anaesthesia is type a of neuraxialanaesthesia technique which involves placing local anaesthetic directly in theintrathecal space (subarachnoid space). The first regional anaesthetictechnique performed was spinal anaesthesia, and the first operation underspinal anaesthesia was performed in 1898 in Germany by August Bier.Itis highly popular among anaesthesiologists and commonly used worldwide.The advantages of an awake patient, minimal drug costs, rapid patient turnovercoupled with fast onset, effective sensory, motor blockade and post-operativeanalgesia with fast post-operative recovery has made it method of choice formany surgical procedures..

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 80

Inclusion Criteria

1)Patients with Body Mass Index (BMI) between 18 -29.9 kg/m2. 2)ASA I and II patients scheduled for elective lower limb orthopaedic surgery with anticipated duration of surgery between 120.

Exclusion Criteria

Patients refusal for central neuraxial block.
Patients with BMI more than 30.
Patients allergic to the drugs under consideration.
Patients having absolute contraindication for spinal anaesthesia.
Primary or metastatic malignancy.
Patients with deformity of spine where drug spread is unpredictable.
Partial effect or failed spinal.
Patients in which space other than L3-L4 inter-vertebral space is used for instituting spinal.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
efficacy of the two drugs hyperbaric Levo-bupivacaine & hyperbaric Ropivacaine in subarachnoid block in terms of sensory and motor block characteristics.	time required for onset and regression of sensory and motor blockade. \| sensory and motor block at 20 minutes

Secondary Outcome Measures

Name	Time	Method
To study effect of drug on intra operative hemodynamic parameters of the patient, total vasopressor requirement between two groups & side effect of drug used if any.	Hemodynamic parameters at 0, 3,6,9,12,15,20,25,30,35,40,45,50,55,60,65,70,75,80,85,90,95,100,105,110,115,120,125,130,135,140,145,150,155,160,165 minutes
Post operative haemodynamic parameters	haemodynamic monitoring at 0,15,30,45,60,75,90,105,120,135,150,165,180,195,210,225,240 minutes

Trial Locations

Locations (1): Department of Anaesthesiology, Dr Rajendra Prasad Government Medical College Kangra At Tanda
🇮🇳
Kangra, HIMACHAL PRADESH, India
Department of Anaesthesiology, Dr Rajendra Prasad Government Medical College Kangra At Tanda
🇮🇳Kangra, HIMACHAL PRADESH, India
Dr Aryan Jarial
Principal investigator
9418130777
aryanjarial6494@gmail.com