Comparison of the Effect of General and Spinal Anesthesia on Umbilical Neutrophil-to-lymphocyte Ratio, Platelet-to-lymphocyte Ratio and Mean Platelet Volume in Patients Undergoing Cesarean Section
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Anesthesia, General
- Sponsor
- Antalya Training and Research Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- neutrophil-to-lymphocyte ratio
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of the study was to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and mean platelet volume (MPV) in patients undergoing cesarean section.
Detailed Description
This study was designed to evaluate the effects of anesthetic techniques (general and spinal anesthesia) on umbilical cord NLR, PLR and MPV in patients undergoing cesarean section. The primary endpoint was to compare the effects of general and spinal anesthesia on umbilical cord NLR. Secondary endpoints were determined the general and spinal anesthesia on routine umbilical cord PLR, MPV and newborn Apgar scores at 1st and 5th min.
Investigators
Eligibility Criteria
Inclusion Criteria
- •18 - 45 years
- •American Society of Anesthesiology (ASA) II-III
- •elective ceserean surgery
Exclusion Criteria
- •declining to give written informed consent
- •under 18 years of age or over 45 years of age
- •factors affecting NLR, PLR and MPV such as preeclampsia, HELLP syndrome or premature rupture of membranes
- •history of neurological and/or neuromucular disease
- •cooperation cannot be established
- •emergency surgery
Outcomes
Primary Outcomes
neutrophil-to-lymphocyte ratio
Time Frame: within 5 minute, following delivery
Evaluate the effects of NLR in patients undergoing cesarean section
Secondary Outcomes
- Newborn Apgar score 1st minute(1st minute after birth)
- platelet-to-lymphocyte ratio(within 5 minute, following delivery)
- Newborn Apgar score 5th minute(5th minute after birth)
- mean platelet volume(within 5 minute, following delivery)