Relationship Between D2 Receptors SPECT and the Apomorphine Test in Patients With OH Dependence (ALC-DRD2-APO)

Phase 2

• Conditions: Alcoholism

• Registration Number: NCT00437177
• Lead Sponsor: Hospital Universitari Vall d'Hebron Research Institute

Brief Summary

OH dependence is associated with DA receptor changes. Both, the apomorphine test and the D2Rec SPECt are usefull for monitoring DA receptor status. We aimed at studying whether DA receptor hypofunction, assessed by means of the apomorphine test and the D2Rec SPECT, is a marker of relapse in detoxified OH dependents patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2007-02-16
• Study First Submitted QC: 2007-02-17
• Study First Posted: 2007-02-19
• Status Verified: 2009-04
• Last Update Submitted: 2009-04-28
• Last Update Posted: 2009-04-29
• Primary Completion: 2009-12
• Study Completion: 2010-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 50

Inclusion Criteria

• alcohol dependence
• alcohol dependence length at least 8 years.
• male
• age 25 - 60 years

Exclusion Criteria

• other drug dependence (except nicotine dependence)
• another major axis I psychiatric diagnosis
• comorbid neurological disorder
• comorbid cardiovascular disorder
• comorbid metabolic disorder
• brain injury
• apomorphine allergy
• iode allergy
• diazepam allergy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
To detertmine the agreement rate of the dopaminergic sensibility assessed by two different techiniques: the apomorphine test and and IBZM SPECT.	3 months

Trial Locations

Locations (1)

Psychiatry Service, Hospital Universitari Vall d'Hebron; 🇪🇸 Barcelona, Catalonia, Spain