Different strategies of heparin management during cardiopulmonary bypass: the effects on anticoagulation and postoperative hemostasis

Completed

• Conditions: Valve disease; valvular obstruction; 10007593

• Registration Number: NL-OMON34395
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 48

Inclusion Criteria

* Patients undergoing valve replacement and/or valve repair surgery
* Age 18-85 years
* Informed consent

Exclusion Criteria

* Re-operations
* Emergency operation
* Patients with insulin-dependent diabetes mellitus
* Patients with a history of hematologic, hepatic or renal diseases
* Patients with Body Mass Index (BMI) over 30 kg/m2

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>* Reduction in postoperative protamine usage</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Improvement of postoperative hemostasis<br /><br>* Hemostatic monitoring (ROTEM Clotting Time (CT), ROTEM Maximum Clot Firmness<br /><br>(MCF) and the shear elastic modulus G (all ROTEM parameters)<br /><br>* Pre-CPB and post-CPB aPTT, PT and Clauss fibrinogen test<br /><br>* Heparin concentration and HR-ACT (both HMS), ACT (Hemochron)<br /><br>* C-reactive protein (CRP), platelet count, perioperative transfusion<br /><br>requirements, perioperative fluid balance<br /><br>* Patient demographics<br /><br>* Surgery time, CPB time, cross-clamp time</p><br>