A Retrospective Study to Evaluate Retention Rate of Topiramate With That of Levetiracetam and Oxcarbazepine in a Long-term Epilepsy Treatment
试验速览
- 阶段
- 不适用
- 入组人数
- 2,500
- 试验地点
- 1
- 主要终点
- Retention rate of topiramate, levetiracetam and oxcarbazepine during 24 months of treatment
研究概览
简要总结
The Objective of this study is to compare 2-year retention rate of topiramate, levetiracetam and oxcarbazepine in a long term epilepsy treatment.
详细描述
Primary objective The Objective of this study is to compare 2-year retention rate of topiramate, levetiracetam and oxcarbazepine in a long term epilepsy treatment.
Secondary objective The main secondary objective of this study is to evaluate confounding factors associated with retention rate of topiramate compared with other anticonvulsants.
- Baseline characteristics
- Seizure Type
- Gender
- Age of onset
- Treatment regimen
- Number of concomitant medication
- Type of drug combination
- Final target dose
- Titration speed
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 15 Years 至 95 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Subjects who began their treatment with topiramate, levetiracetam or oxcarbazepine as mono or add-on therapy with conventional drugs.
- •Subjects who are with partial or generalized epilepsy
排除标准
- •Subjects who administered combination therapy in topiramate, levetiracetam or oxcarbazepine
- •Subjects who have past experience of surgery for epilepsy treatment
- •Subjects who were not followed up for at least 1 year
结局指标
主要结局
Retention rate of topiramate, levetiracetam and oxcarbazepine during 24 months of treatment
时间窗: 24months
Overall retention rates of three treatment groups at two years will be presented in patient number (% of continuation or discontinuation).
次要结局
- Evaluate the confounding factors affecting the retention rate(24 months)
- Evaluate the response rate through seizure reduction (≥75%, ≥50%) in 2-year treatment with each antiepileptic drugs (topiramate, levetiracetam, oxcarbazepine)(24 months)
研究者
Sang Kun Lee
Professor
Seoul National University Hospital