Predrainage administration of Dopamine in the Renal function of selected patients with Obstructive Jaundice

Completed

• Conditions: Obstructive jaundice; Other diseases of biliary tract; Digestive System

• Registration Number: ISRCTN14198655
• Lead Sponsor: Reina Sofia University Hospital (Spain)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2010-01-15
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

1. Malignant OJ with serum bilirubin higher than 6 mg/dl
2. Ultrasound evidence of extrahepatic and intrahepatic bile duct dilation (more than 8 mm and 4 mm respectively)
3. Feasibility of internal endoscopic biliary drainage
4. Aged 35 to 76 years, either sex

Exclusion Criteria

1. Cholangitis
2. Acute pancreatitis
3. Heart disease
4. Arterial hypertension
5. Chronic lung disease
6. Use of diuretics
7. Chronic renal failure

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Renal function (CrCl), assessed at admission, before drainage, as well as 24 hours and 72 hours after biliary drainage.

Secondary Outcome Measures

Name	Time	Method
Assessed at admission, before drainage, as well as 24 hours and 72 hours after biliary drainage:<br>1. Extracellular water (ECW) volume <br>2. Serum leves of aldosterone, renin, atrial natriuretic peptide (ANP), antidiuretic hormone (ADH), endothelin-1 (ET-1)<br>3. Urine prostaglandin E2 (PgE2)