A Prospective Study of Residual Inflammatory Risk and the Impact on Clinical Outcomes in Patients Undergoing Percutaneous Coronary Interventions
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- hsCRP
- Sponsor
- Wuhan Union Hospital, China
- Enrollment
- 1408
- Locations
- 1
- Primary Endpoint
- Major adverse cardiovascular events (MACEs)
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Coronary heart disease (CAD) is caused by myocardial ischemia, hypoxia or necrosis due to coronary artery stenosis, spasm or obstruction. Although standard drug therapy can greatly improve the prognosis of patients with CAD after percutaneous coronary interventions (PCI), these patients are still at high risk of major adverse cardiovascular events (MACE).
At present, the concept of residual inflammation risk (RIR) has aroused widespread concern. RIR is an important independent risk in patients with CAD. Foreign studies indicate that hsCRP ≥ 2mg / L is the definition standard of RIR in CAD. In China, there is no defined value of RIR for patients undergoing PCI, and the incidence of RIR has not been investigated clearly. At the same time, the impact of dynamic changes of hsCRP on MACE in PCI population needs to be further explored. Therefore, in this study, we plan to recruit patients undergoing PCI, and observe the impact of RIR by serial hsCRP measurements on the prognosis of these patients followed up for 5 years.
Detailed Description
Serial hsCRP measurements with ≥ 4 weeks between both measurements are defined in this analysis. Time-to-event is measured from first hsCRP measurement.
Investigators
Xiang Cheng
Head of department of cardiology, Wuhan Union Hospital, China
Wuhan Union Hospital, China
Eligibility Criteria
Inclusion Criteria
- •Participants who understand and sign the informed consent form voluntarily;
- •Age ≥ 18 years old and ≤ 80 years old, regardless of sex;
- •The hospitalized patients with coronary heart disease undergoing PCI;
- •Complete all planned PCI during hospitalization
Exclusion Criteria
- •Patients do not receive standardized treatment according to guidelines after being diagnosed with coronary heart disease;
- •Uncontrolled infectious diseases during the screening period;
- •In the screening stage, patients with immune diseases or immune-related diseases such as systemic lupus erythematosus, asthma, inflammatory bowel disease, gout, malignant tumor and so on;
- •Long-term use of non-steroidal anti-inflammatory drugs, hormones, immunomodulatory and chemotherapeutic drugs during the study period;
- •Surgical or interventional treatment was performed within 3 months before the screening period;
- •Pregnant women, lactating women or women of childbearing age who do not use effective contraceptives;
- •Participated in other clinical trials within 3 months before the screening period;
- •The researchers determined that other conditions in which the patient was not suitable to participate in the clinical trial.
Outcomes
Primary Outcomes
Major adverse cardiovascular events (MACEs)
Time Frame: 60 months
Composite endpoint of all-cause death, nonfatal myocardial infarction, nonfatal stroke, and revascularization due to ischemia
Secondary Outcomes
- Nonfatal myocardial infarction(60 months)
- Revascularization due to ischemia(60 months)
- In-stent thrombosis(60 months)
- Nonfatal stroke(60 months)
- Bleeding(60 months)
- Cardiovascular death(60 months)
- All-cause death(60 months)