Beta-1 Adrenergic Inhibition to Reduce Cardiac Injury and Inflammation After Subarachnoid Hemorrhage (BADCATS)

Phase 4

Not yet recruiting

• Conditions: Non-Traumatic Subarachnoid Hemorrhage

• Registration Number: NCT06569212
• Lead Sponsor: Madeleine Puissant

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-8-19
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Not yet recruiting
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

Inclusion Criteria:<br><br> - >18 years of age<br><br> - Neuro-imaging confirmed non-traumatic subarachnoid hemorrhage<br><br>Exclusion Criteria:<br><br> - Traumatic cause of subarachnoid hemorrhage (e.g. fall, motor vehicle accident, other<br> blunt trauma) as this is a different mechanism of hemorrhage.<br><br> - Other forms of traumatic or non-traumatic intracranial bleed including intracerebral<br> hemorrhage (ICH), subdural hemorrhage, epidural hemorrhage<br><br> - Pregnancy (as the study medication, metoprolol, has FDA Pregnancy Category C rating)<br><br> - Unstable vital signs not amenable to beta-1 adrenergic receptor inhibitor (B1ARi)<br> administration including:<br><br> - Systolic blood pressure < 80 mmHg not stabilized on vasopressor medications<br><br> - Heart rate < 50 bpm associated with hypotension<br><br> - Patients requiring vasopressor agents due to hypotension (SBP <80 mmHg)<br><br> - Other vital sign exclusion at the discretion of the treatment team<br><br> - Previous history of severe heart failure (Stage C or D Heart Failure and/or NYHA<br> Class III or IV)<br><br> - Patient or legally authorized representative unwilling to provide informed consent

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Delta QTc length;Delta neutrophil activity

Secondary Outcome Measures

Name	Time	Method
Adverse events;Number of patients with evidence of cardiac injury;Need for Vasopressors;Sympathetic Nervous System (SNS) Activity;Neutrophil Activity;Evidence of Clinical Vasospasm;ICU Length of Stay (LOS);Hospital Length of Stay (LOS);In-hospital mortality