The effect of Beta-Adrenergic receptor blockade on sympathetic activity and Coagulation in patients with Heart failure (BACH-F study).
Completed
- Conditions
- 1. Heart failure<br />2. Hemostasis<br />3. Sympathetic activity.
- Registration Number
- NL-OMON21698
- Lead Sponsor
- P.W. Kamphuisen, internist, Vasculair Geneeskundige.
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 80
Inclusion Criteria
1. Between 18 and 80 years of age, competent and willing of giving informed consent;
2. With stable symptoms of chronic heart failure (NYHA II-III);
Exclusion Criteria
1. With a history of adverse reaction on beta-blockers;
2. With a contraindication to â-blocker therapy (Sick-sinussyndrome, second and third AV-block), severe hypotension (systolic blood pressure < 100 mm Hg), cardiogenous shock, clinical relevant sinusbradycardia. Asthma, COPD. Liverfunctiondisorder (defined as elevation of aspartamine transaminase, alanine transaminase or bilirubin levels more than three times upper limit of normal range), renal disease (calculated creatinine clearance <50ml/min, using Cockcroft¡¯s formula). Insulin dependent diabetes mellitus.);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Sympathetic activity as measured by spectral analysis of blood pressure and heart rate vaiability and by MIBG-scintigraphy. Hemostasis (platelet activity and thrombin generation and other coagulaiton factors). Both measured at the end of each treatment period. In healthy volunteers also as a baseline measurement.
- Secondary Outcome Measures
Name Time Method Central blood pressure / augmentation index.