Efficacy of beta-blocker on the autonomic nervous activities and the onset of atrial fibrillation or flutter in patients after cardiac surgery.
Phase 4
Recruiting
- Conditions
- Atrial fibrillation or flutter following cardiac surgery
- Registration Number
- JPRN-UMIN000004216
- Lead Sponsor
- Shimane University Faculty of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients with chronic or paroxysmal atrial fibrillation 2. Patients receiving antiarrhythmic agents: Ia, IIc and IV groups 3. Patients with sick sinus syndrome 4. Patients with higher than 2 degree atrioventricular block 5. Heart failure patients with EF less than 30% 6. Patients with bronchial asthma 7. Patients receiving beta blockers
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method This study is a randomized open-label controlled trial. An ultra-short acting beta- blocker (landiolol hydrochloride) is intravenously given immediately after cardiac surgery, followed by oral carvedilol in the patients randomized to treatment group. The incidence of postoperative atrial fibrillation / flutter during 7days after operation is evaluated as a major outcome.
- Secondary Outcome Measures
Name Time Method The autonomic changes are evaluated by the analysis of heart rate variability (Holter recording analysis) as secondary outcomes.