NCT00695045已完成不适用
Determination of the Efficacy and Side-Effect Profile of Lower Doses of Intrathecal Morphine in Patients Undergoing Total Knee Arthroplasty
University College Hospital Galway0 个研究点目标入组 60 人开始时间: 2003年7月最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 主要终点
- pain
研究概览
简要总结
This study is designed to explore the efficacy lower doses of intra-spinal morphine for pain relief and side effect profiles of same in the setting of Total Knee Replacement.We hypothesized that a dose greater than that used in Total Hip Replacement was needed and wished to find a dose which was effective but had a low side effect profile.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients for elective total knee arthroplasty
排除标准
- •No contraindication to spinal
- •No allergy to morphine, rescue analgesia or anti-emesis treatment.
研究组 & 干预措施
1
Experimental
patients in this group got 100mcg of intrathecal morphine.
干预措施: intra thecal morphine (Drug)
2
Experimental
patients in this group got 200 mcg intrathecal morphine
干预措施: intra thecal morphine (Drug)
3
Experimental
patients in this group given 300 mcg intrathecal morphine.
干预措施: intra thecal morphine (Drug)
结局指标
主要结局
pain
时间窗: 24 hours
次要结局
- nausea and vomiting(24 hours)
- pruritus(24 hours)
- sedation(24 hours)
研究者
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