Comparative effects of Buprenorphine and Morphine as adjuvants to Bupivacaine spinal anesthesia in patients undergoing infra-umbilical surgeries - A Prospective study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- To compare the duration of postoperative analgesia of buprenorphine and morphine when given intrathecally with hyperbaric bupivacaine
研究概览
简要总结
Postoperative analgesia is generally the domain of the anaesthesiologist.Intrathecal morphing has been considered as the most effective opioid because of its potency and prolonged duration of action.Buprenorphine intrathecally also provides good postoperative pain relief without prolonging motor or sensory blockade. Hence, this study is designed to compare the effects of Buprenorphine and Morphine as adjuvants to Bupivacaine spinal anesthesia in patients undergoing infraumblical surgeries. This is a prospective study involving 30 patients in each group. Group B will receive 2.8ml of 0.5% hyperbaric bupivacaine with Buprenorphine 60mcg while, Group M will receive 2.8 ml of 0.5% hyperbaric bupivacaine with 100 mcg of Morphine. Time to first rescue analgesia is the primary objective and secondary objectives include time taken to acheive maximum sensory and motor blockade, vital parameters, adverse effects perioperatively.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •ASA Physical status 1 or 2 Presenting for infraumblical surgeries Patients who provide consent for the study.
排除标准
- •Patient allergic to the drug ASA Physical status 3 and above , acute or chronic respiratory disease, cognitive or psychiatric disturbances Any contraindication to subarachnoid block Pregnant women Day care procedures Patients who do not give consent.
结局指标
主要结局
To compare the duration of postoperative analgesia of buprenorphine and morphine when given intrathecally with hyperbaric bupivacaine
时间窗: 2, 4, 8, 12, 24 hours of postoperative analgesia
次要结局
- Time taken to achieve maximum sensory and motor block(Intraoperative hemodynamic changes like bradycardia and hypotension and intraoperative side effects like nausea, vomiting and pruritis)