To compare the analgesic effect of buprenorphine through epidural and trandermal routes in patients undergoing hysterectomy.
Phase 4
Recruiting
- Conditions
- Undergoing Hysterectomy
- Registration Number
- CTRI/2018/05/013594
- Lead Sponsor
- Anju Krishnan
- Brief Summary
Buprenorphine is a potent analgesic widely used for postoperative analgesia especially through the epidural route. Transdermal patches of buprenorphine provide an easy, safe and sustained method of drug delivery and avoids multiple pricks. This study tries to evaluate efficacy of transdermal buprenorphine in providing postoperative analgesia compared to epidural buprenorphine infusion. Side effects like headache, nausea, vomiting , respiratory depression , pruritis and dizziness will also be watched for.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Female
- Target Recruitment
- 174
Inclusion Criteria
- a)Age between20 and 65 years.
- American Society of Anaesthesiologists ASA I OR II.
- Expected hospital stay after intervention atleast for 72 hrs.
- Weight 45kg -65kg.
Exclusion Criteria
- Any chronic pain syndromes.
- Chronic obstructive pulmonary disease.
- Any history of hypersensitivity to opioids or patch additives.
- Obstructive sleep apnoea.
- Psychiatric disorders which impact on appropriate data collection.
- Surgeries lasting for more than 2 hours.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Postoperative analgesia will be assessed using numerical rating scale. 2hr, 4hr, 12hr, 24hr,36hr, 48hr, 60hr, 72hr after surgery
- Secondary Outcome Measures
Name Time Method side effects like nausea, vomiting, pruritus, headache, diziness 2hr, 4hr, 12hr, 24hr,36hr, 48hr, 60hr, 72hr after surgery
Trial Locations
- Locations (1)
Government Medical College Kozhikode
🇮🇳Kozhikode, KERALA, India
Government Medical College Kozhikode🇮🇳Kozhikode, KERALA, IndiaAnju KrishnanPrincipal investigator919747859448anjukvk12@gmail.com