The effect of vitamin D in Optic Neuritis outcome
- Conditions
- Optic neuritis.Optic neuritis
- Registration Number
- IRCT201205319919N1
- Lead Sponsor
- Isfahan University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 30
Entry criteria were as follows: (1) optic neuritis male or female patients with age range of 20-40 years, (2) patients should not fulfill the 2005 revised Mc Donald Criteria for multiple sclerosis, at the time of inclusion in the study,(3) serum 25(OH)D level of less than 30ng/ml (4) seronegativity for anti-aquaporin4 and other autoimmune antibodies,
Exclusion criteria are:(1) patients who have used vitamin D supplements at a level higher than 400IU/day before the onset of optic neuritis,(2)patients who used any medication that could influence the prognosis of optic neuritis (e.g. ß interferon) during the 12 months follow-up period,(3) women who were pregnant or breast feeding,(4) patients with kidney or liver dysfunction, (5)patients who demonstrated poor compliance with instructions to take vitamin D or placebo,or who failed to attend for follow- up visits, MRI scanning and vitamin D measurements during the study,(6)patients with a history of nephrolithiasis and(7) patients suffering from concurrent granulomatous diseases.
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence rate of new demyelinative attack(s). Timepoint: before and after the study. Method of measurement: complain(s) of patients, physical examination and MRI.
- Secondary Outcome Measures
Name Time Method The changes in MRI lesions. Timepoint: before and after study,during new attack(s). Method of measurement: counting of MRI plaques.