Factors Influencing Analgesic Consumption in the Early Postoperative Period: A Prospective Observational Study in the Post-Anesthesia Care Unit
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 254
- 试验地点
- 1
- 主要终点
- Total Analgesic Consumption in the PACU
研究概览
简要总结
Postoperative pain remains a significant clinical challenge that directly affects patient recovery, functional outcomes, and overall quality of care. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic pain. The post-anesthesia care unit (PACU) represents a critical phase in which pain is actively assessed and managed, and analgesic consumption during this period serves as an objective indicator of analgesic requirements and effectiveness of perioperative pain strategies.
This prospective observational study aims to identify patient-related, surgical, and anesthesia-related factors influencing analgesic consumption in the early postoperative period among adult patients admitted to the PACU following elective surgery. No additional interventions will be performed, and all perioperative management will follow routine clinical practice. Data will be collected prospectively from clinical records, anesthesia charts, and PACU monitoring forms.
The primary outcome is total analgesic consumption during the PACU stay. Secondary outcomes include pain intensity assessed using a standardized pain scale at PACU admission and discharge, requirement for rescue analgesia, incidence of postoperative nausea and vomiting, and length of stay in the PACU.
The findings of this study are expected to contribute to the identification of patients at higher risk for increased analgesic requirements and to support the development of individualized pain management strategies, ultimately improving perioperative care quality and patient outcomes.
详细描述
Postoperative pain is a major clinical concern that significantly affects recovery, patient satisfaction, and overall perioperative outcomes. Inadequate pain control in the early postoperative period is associated with delayed mobilization, increased risk of complications, prolonged hospital stay, and the development of chronic postoperative pain. Therefore, early identification of factors influencing analgesic requirements is essential for optimizing individualized pain management strategies.
The post-anesthesia care unit (PACU) represents a critical period during which patients are closely monitored following surgery, and pain management is actively adjusted. Analgesic consumption during this phase provides an objective and clinically relevant measure of pain management adequacy. However, analgesic requirements may vary widely depending on patient-related factors (such as age, sex, and body mass index), surgical characteristics (type and duration of surgery), and anesthesia-related variables (anesthetic technique, intraoperative analgesic administration, and use of regional anesthesia).
This study is designed as a single-center, prospective observational study conducted in the post-anesthesia care unit of a tertiary oncology hospital. Adult patients undergoing elective surgical procedures will be included. No additional interventions will be performed, and all perioperative care will be administered according to routine clinical practice. Data will be collected prospectively from anesthesia records, PACU monitoring forms, and hospital electronic systems.
The primary outcome is total analgesic consumption during the PACU stay. Secondary outcomes include pain intensity at PACU admission and discharge, requirement for rescue analgesia, incidence of postoperative nausea and vomiting, and length of stay in the PACU.
The findings of this study are expected to contribute to the identification of patients at higher risk for increased analgesic requirements in the early postoperative period. These results may support the development of individualized and more effective pain management strategies and improve overall perioperative care quality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults aged 18 years and older
- •Undergoing elective surgical procedures
- •Admitted to the post-anesthesia care unit (PACU) after surgery
- •Receiving general and/or regional anesthesia
- •Able to provide informed consent
排除标准
- •Patients younger than 18 years
- •Emergency surgical procedures
- •Patients transferred directly to the intensive care unit postoperatively
- •PACU stay shorter than 30 minutes
- •Patients unable to communicate or assess pain
- •Incomplete clinical records
- •Refusal to participate in the study
研究组 & 干预措施
PACU Observational Cohort
This study consists of a single observational cohort of adult patients undergoing elective surgery and subsequently monitored in the post-anesthesia care unit (PACU). No intervention is applied as part of the study. All patients receive standard perioperative care according to institutional clinical practice. Data on analgesic consumption, pain scores, and perioperative variables are collected prospectively to evaluate factors influencing analgesic requirements in the early postoperative period.
干预措施: Observational Assessment (Other)
结局指标
主要结局
Total Analgesic Consumption in the PACU
时间窗: During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively)
Total amount of analgesic medications administered to patients during their stay in the post-anesthesia care unit (PACU). Analgesic consumption will be recorded and standardized (e.g., converted to morphine equivalents if applicable) to allow comparison across patients.
次要结局
- Pain Intensity at PACU Admission(At PACU admission (within the immediate postoperative period))
- Pain Intensity at PACU Discharge(At PACU discharge (within approximately 0-4 hours postoperatively))
- Requirement for Rescue Analgesia in the PACU(During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively))
- Incidence of Postoperative Nausea and Vomiting in the PACU(During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively))
- Length of Stay in the PACU(During PACU stay (from admission to discharge, within approximately 0-4 hours postoperatively))
研究者
Mustafa Kemal ŞAHİN
Principal Investigator
Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital