OPTIMAL DIURETIC THERAPIES FOR ACUTE HEART FAILURE WITH VOLUME OVERLOAD

Hvidovre Hospital0 sites939 target enrollmentJanuary 11, 2024

Overview

No summary available.

Registry

who.int

Start Date

January 11, 2024

End Date

TBD

Last Updated

last year

Study Type

Interventional clinical trial of medicinal product

Sex

All

Sponsor

•1\.Aged 18 years or older. 2\.Admitted acutely with a clinical diagnosis of acute heart failure accompanied by volume overload\*. 3\.Display risk of diuretic resistance, characterized by: 1\.Daily loop\-diuretics administration for a minimum of 7 days before admission, or 2\.Insufficient decongestion observed in the preceding 24 hours (weight reduction \<500g or negative fluid balance \<1L) despite being treated with high\-dose IV loop diuretic (equivalent to \=120 mg IV furosemide within 24 hours). 4\.Clinical signs of congestion, indicated by one or more of the following: pitting peripheral edema, ascites, elevated jugular venous pressure, or radiological/ultrasonic evidence of pulmonary congestion. \*Volume overload is characterized by at least two of the subsequent signs of congestion: a. Clear pitting edema b. Uni\- or bilateral pleural effusion c. Ascites d. Pulmonary congestion or edema

•1\.Acute coronary syndrome 2\.Systolic blood pressure \<85 mmHg 3\.Use of renal replacement therapy or ultrafiltration in\-hospital before study inclusion 4\.Treatment with acetazolamide or metolazone during the index hospitalization prior to randomization