OPTIMAL DIURETIC THERAPIES FOR ACUTE HEART FAILURE WITH VOLUME OVERLOAD

Hvidovre Hospital0 个研究点目标入组 939 人开始时间: 2024年1月11日最近更新: 2024年7月22日

适应症

试验速览

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•1.Aged 18 years or older. 2.Admitted acutely with a clinical diagnosis of acute heart failure accompanied by volume overload*. 3.Display risk of diuretic resistance, characterized by: 1.Daily loop-diuretics administration for a minimum of 7 days before admission, or 2.Insufficient decongestion observed in the preceding 24 hours (weight reduction <500g or negative fluid balance <1L) despite being treated with high-dose IV loop diuretic (equivalent to =120 mg IV furosemide within 24 hours). 4.Clinical signs of congestion, indicated by one or more of the following: pitting peripheral edema, ascites, elevated jugular venous pressure, or radiological/ultrasonic evidence of pulmonary congestion. *Volume overload is characterized by at least two of the subsequent signs of congestion: a. Clear pitting edema b. Uni- or bilateral pleural effusion c. Ascites d. Pulmonary congestion or edema

•1.Acute coronary syndrome 2.Systolic blood pressure <85 mmHg 3.Use of renal replacement therapy or ultrafiltration in-hospital before study inclusion 4.Treatment with acetazolamide or metolazone during the index hospitalization prior to randomization

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