Evaluating the Role of Cystatin C and Creatinine as Markers of Renal Recovery in Critically Ill Patients After Acute Kidney Injury.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 336
- 试验地点
- 1
- 主要终点
- Renal function
研究概览
简要总结
This is a cohort study in which patients who survive Acute Kidney Injury (AKI) during intensive care unit (ICU) admission are recalled at 3-6 months and renal function tests are performed.
The purpose of the study is describe renal function in AKI survivors at follow-up.
Additional aims are to determine how well admission values of renal function markers perform as predictors of renal function at follow-up and whether estimates of renal function at follow-up differ depending on which renal function marker is used.
详细描述
Type of study: Cohort study with prospectively collected clinical data cross-matched with local & national databases.
Source population: Patients suffering from AKI on a mixed intensive care unit, at the Karolinska University Hospital, Solna.
Setting: Single centre, Central Intensive Care unit Karolinska University hospital, Solna, Stockholm from September 2008 and May 2011.
Exposure: AKI on ICU and grade of AKI according to the RIFLE criteria Intervention: none
Outcome: Renal function 3 months after ICU discharge according to creatinine and Cystatin C measurements.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults treated on Intensive care with AKI (RIFLE criteria)
- •Survival 3 months after discharge.
- •Admission during September 2008-May 2011
排除标准
- •Under 18 years
- •Unable to give consent.
- •Admission during a time when study staff not working.
- •Death before 3 month follow-up
- •No Swedish personal identification number
结局指标
主要结局
Renal function
时间窗: 3-9 months
Renal function as defined by estimated glomerular filtration rate (eGFR)using seri Creatinine and Cystatin C at follow-up
次要结局
- Mortality(2 years)
研究者
Claire Rimes-Stigare
Doctor
Karolinska Institutet