Predicting Acute Kidney Injury in Critically Ill Trauma Patients Using Metalloproteinase 2 (TIMP2) and Insulin-like Growth Factor Binding Protein7 (IGFBP 7)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Acute Renal Injury
- Sponsor
- Loma Linda University
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Measurement of u rinary metalloproteinase 2 (TIMP-2) and Insulin-like growth factor binding protein 7 (IGFBP-7) biomarker elevation that corresponds to acute kidney injury by creatinine and urine output
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Acute kidney injury (AKI) in critically ill trauma patients has been shown to significantly increase mortality, length of stay, and costs, however detection has proven difficult as markers like elevated creatinine and decreased urine output may take days to manifest and are late indicators of AKI. The combination of two urinary biomarkers, Tissue Inhibitor of Metalloproteinase 2 (TIMP-2) and Insulin-like Growth Factor Binding Protein 7 (IGFBP-7), has been shown to increase within 12 hours following renal insult, allowing assessment of risk for developing acute kidney injury. Therefore, the investigators plan to assess if acute kidney injury in critically ill trauma patients can be determined earlier using urinary TIMP-2 and IGFBP-7 via the NephroCheck testing system. These markers have not been specifically evaluated in trauma patients at risk of AKI.
Investigators
Ronak Raval
MD
Loma Linda University
Eligibility Criteria
Inclusion Criteria
- •trauma patients with multiple injuries;
- •abdominal injuries;
- •crush injuries;
- •those who present in shock (systolic blood pressure \<90 or mean arterial pressure \<65);
- •require blood transfusions, vasopressors or mechanical ventilation
Exclusion Criteria
- •known pregnancy;
- •patients under 21 years of age;
- •known moderate to severe AKI prior to enrollment and end stage renal disease. known moderate to severe AKI prior to enrollment and end stage renal disease
Outcomes
Primary Outcomes
Measurement of u rinary metalloproteinase 2 (TIMP-2) and Insulin-like growth factor binding protein 7 (IGFBP-7) biomarker elevation that corresponds to acute kidney injury by creatinine and urine output
Time Frame: one year