Clinical significance of new OCT parameters in diagnosis and follow-up of primary open angle glaucoma

Completed

Conditions: glaucoma
ocular hypertension
10018307

Registration Number: NL-OMON37906

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 240

Inclusion Criteria

• Patients with ocular hypertension, suspect glaucoma, early glaucoma and moderate glaucoma, 18 years of age or older
• Patients with open anterior chamber angle
• VA > 20/30
• Able to perform reliable visual field test
• Willing and able to sign the informed consent.

Exclusion Criteria

• Media opacities, like cataract, that will make it impossible to make reliable images with the OCT
• Hypermetropia more than S+5 dioptres, or myopia more than S-7 dioptres
• Presence of other diseases including retinal disorders that may influence visual acuity, visual field testing or the results of structural measurements done by SD-OCT
• Presence of signs of secondary glaucoma such as inflammatory or neovascular causes, with the exception of pigment dispersion syndrome and pseudoexfoliation syndrome

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Sensitivity and specificity of the new SD-OCT parameters will be compare with<br /><br>the sensitivity and specificity of the RNFL thickness measurements and the<br /><br>visual field testing. We will investigate to what extent these new parameters<br /><br>can contribute in differentiating patients from healthy controls, between<br /><br>stages of glaucoma, between patients with a normal and an elevated baseline<br /><br>IOP, and to establish the accuracy to detect progression of glaucoma.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- visual acuity<br /><br>- intra ocular pressure<br /><br>- visual field test outcome<br /><br>- RNFL thickness<br /><br>- GCL thickness<br /><br>- lamina cribrosa thickness<br /><br>- peripapillary choroid thickness</p><br>