Vascular function in polycystic ovary patients after treatment with metformin: it’s role in polycystic-ovary-syndrome-associated insulin resistance.
Completed
- Conditions
- polycystic ovary syndrome
- Registration Number
- NL-OMON28442
- Lead Sponsor
- VU University Medical Center, Amsterdam, the Netherlands
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 40
Inclusion Criteria
1. PCOS as judged in early routine patient work-up by 3 out of the following 4 criteria:
a. Oligo (mean length of the menstrual cycle > 35 days) - or amenorrhoea (based on history of oligomenorrhoea);
Exclusion Criteria
1. Cardiovascular disease (hypertension (>160/90 mmHg), stroke, coronary artery disease, peripheral vascular disease, heart failure);
2. Diabetes mellitus (according to ADA criteria);
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Vascular function after metformin therapy compared to vascular function at baseline (micro and macrovascular measurements).
- Secondary Outcome Measures
Name Time Method