Differential diagnosis and follow-up of cystic neoplasms of the pancreas: advanced radiologic imaging and cyst fluid analysis

Conditions: cystic tumors of the pancreas
neoplastic cysts
10018008

Registration Number: NL-OMON30334

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 150

Inclusion Criteria

Cystic lesion on cross-sectional imaging (percutaneous ultrasound and/or CT scan and/or MR scan)
Suspicion of a pancreatic neoplasm

Exclusion Criteria

Acute phase of an acute pancreatitis
PT-INR>1.5, PTT>50, trombocytes<50.000
Synchronic malign neoplasm in stomach / colon / rectum / lung / breast / liver

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary aims are to identify new means to improve the differential<br /><br>diagnosis of pancreatic cystic lesions to guide patient management and to<br /><br>assess the biological behaviour of the pancreatic cystic lesions.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To describe a large single-centre experience with pancreatic cystic lesions,<br /><br>including presenting signs and symptoms and methods of diagnosis.<br /><br><br /><br>To assess the development and natural behaviour of pancreatic cysts according<br /><br>to a predefined follow-up scheme/ regimen.<br /><br><br /><br>To identify new biomarkers of pancreatic cystic neoplasms using proteomics<br /><br>technology and assess their feasibility and reliability compared to well-known<br /><br>tumor markers and enzymes for pathological diagnosis in patients with a<br /><br>pancreatic cystic lesion.<br /><br><br /><br>To make recommendations for the accurate diagnosis and optimal treatment of<br /><br>patients with all types of pancreatic cystic lesions.</p><br>