Biomarkers to target antibiotics and steroid therapy in chronic obstructive pulmonary disease (COPD) exacerbations

Completed

• Conditions: Chronic obstructive pulmonary disease (COPD); Respiratory; Other chronic obstructive pulmonary disease

• Registration Number: ISRCTN92422949
• Lead Sponsor: niversity Hospitals of Leicester NHS Trust (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-07-30
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 106

Inclusion Criteria

1. Provision of informed consent
2. Male or female
3. Aged 40 years or over
4. Diagnosis of COPD
5. Greater than one exacerbation requiring antibiotics and or corticosteroids in the preceding year

Exclusion Criteria

1. Current active respiratory tuberculosis
2. Upon questioning the patient known human immunodeficiency virus (HIV) infection or positive hepatitis B or C
3. Known inability to produce a sputum sample during the induced sputum procedure
4. Clinically relevant disease or disorder (past or present) which in the opinion of the investigator may either put the subject at risk because of participating in the study or may influence the results of the study or the subject's ability to participate in the study
5. Any clinically relevant lung disease other than COPD
6. Donation of blood within 3 months or during the study (for other than study purpose)
7. Pregnancy or lactation

Study & Design

• Study Type: Interventional
• Study Design: Not specified