ong-term outcomes of pulmonary function in HIV-infected patients with a history of Pneumocystis jirovecii pneumonia

Completed

Conditions: gas transport disorder in the lungs
Pneumocystis Jirovecii Pneumonia
10037072

Registration Number: NL-OMON55803

Lead Sponsor: MC Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

HIV-infected patients with and without a history of Pneumocystis Jirovecii
Pneumonia

Exclusion Criteria

* Active pulmonary infection or cardiac decompensation at the moment of
pulmonary function testing
* Chronic condition which could influence the pulmonary function testing
* Unexplained dyspnoea, tachypnoea or other acute respiratory complaints at the
moment of pulmonary function testing (<3 weeks of duration)
* In the opinion of treating physician, not being able to cooperate during the
pulmonary function testing.

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The prevalence of abnormalities in pulmonary function testing like obstructive<br /><br>or restrictive lung disease and CO diffusion impairment. The following<br /><br>parameters will be assessed: Vital capacity, Forced Expiratory Volume in 1<br /><br>second (FEV1) and carbon-dioxide diffusion capacity. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. to establish if the prevalence of obstructive ventilatory disorder in HIV<br /><br>infected patients with a history of PJP is significantly higher than in the HIV<br /><br>positive matched controls;<br /><br>2. to establish if the prevalence of restrictive ventilatory disorder in HIV<br /><br>infected patients with a history of PJP is significantly higher than in the HIV<br /><br>positive matched controls;<br /><br>3. to establish if there is relation between diminishing of de pulmonary<br /><br>diffusion capacity and the self-reported pulmonary complaints;<br /><br>4. to establish if the self-reported pulmonary complaints are more prevalent in<br /><br>the group of HIV patients with history of PJP compared to matched controls. </p><br>