THE ORAL CAVITY AS A SOURCE OF FEBRILE NEUTROPENIA
Recruiting
- Conditions
- Febrile neutropeniaDental focus/fociFebriele neutropenieDentogeen focus/foci
- Registration Number
- NL-OMON28600
- Lead Sponsor
- Academic Medical Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 200
Inclusion Criteria
Diagnosed with a solid cancer, lymphoma or multiple myeloma
- Planned treatment with myelosuppressive chemotherapy with FN risk of 10%-20% (with or without targeted therapies or hormonal therapy)
Exclusion Criteria
- Patients unable to give written informed consent
- Patients <18 years
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To identify oral/dental foci prior to the start of chemotherapy and to determine whether these are associated with the development of FN, bacteremia and/or SIRS/sepsis
- Secondary Outcome Measures
Name Time Method To assess whether oral/dental foci are associated with the incidence and severity of OM <br /><br>To assess whether OM is associated with FN, bacteremia and SIRS/sepsis <br /><br>To document microbiological shifts (bacteria/fungi) in oral rinsing samples taken prior to chemotherapy and during standard care visits thereafter using an innovative open-end technique and to investigate any associations with the development of OM <br /><br>To assess retrospectively whether any microorganisms found in blood samples from patients with FN are (likely) derived from the oral cavity using DNA finger printing techniques and Q-PCR. <br /><br>To explore whether genetic polymorphisms in candidate genes demonstrate an increased risk for the development of severe OM, FN, and SIRS/sepsis <br /><br>Differences in inflammation parameters in peripheral blood at baseline and when presenting with fever and/or mucositis.