asopharyngeal Colonization, Distribution of Serotypes, and Antimicrobial Drug Susceptibility among Streptococcus pneumoniae / Haemophilus influenzae before and after Introducing of 7-valent Pneumococcal Conjugate Vaccine and H.influenzae type b vaccine in Sado, Japan -SADO Birth Cohort study
Not Applicable
- Conditions
- asopharyngeal carriage
- Registration Number
- JPRN-UMIN000010996
- Lead Sponsor
- Otolaryngology-Head and Neck Surgery, Wakayama Medical University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 350
Inclusion Criteria
Not provided
Exclusion Criteria
1. Newborns had plan to move to other areas within 3 years 2. Newborns had congenital malformation. 3. For other reasons, newborns determined to be inappropriate for study entry by investigator.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Colonization rate of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age. 2. Capsular serotypes of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age.
- Secondary Outcome Measures
Name Time Method 1. Minimum inhibitory concentration (MIC) of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age. 2. Antimicrobial resistance genes of S. pneumoniae and H. influenzae at 1-, 4-, 7-, 10-, 18-, 36-month of age. 3. Serum antibody titer of infant aged a month carried pneumococcus in pre-and post- PCV7 vaccination