Does extranasal colonization of the throat and perineal area with Staphylococcus aureus occur?

• Conditions: endogenous Staphylococcus aureus infection; infection with a bacterium which belongs to the normal flora of individuals; 10004018

• Registration Number: NL-OMON37698
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 200

Inclusion Criteria

Volunteers above the age of 18 years.

Exclusion Criteria

Antibiotic usage in the last 4 weeks.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>- In the first phase of the study the endpoint is to define the natural S.<br /><br>aureus carriage state of the nose, the throat and the perineal area over a<br /><br>follow-up period of 12 weeks among a cohort of volunteers. At the end of this<br /><br>phase those volunteers who, considering the definition (chapter 6.2 of<br /><br>protocol), are categorized as non-carriers for S. aureus will stop<br /><br>participating. The remaining volunteers will be included in the second phase of<br /><br>the study.<br /><br>- In the second phase the effect of nasal eradication of S. aureus (using nasal<br /><br>mupirocin) on nasal, throat and perineal carriage with S. aureus will be<br /><br>determined.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>