Radiofrequency Ablation in Treating Patients Who Are Undergoing Surgery for Thyroid Cancer
- Conditions
- Head and Neck Cancer
- Registration Number
- NCT00103155
- Lead Sponsor
- University of California, San Francisco
- Brief Summary
RATIONALE: Radiofrequency ablation uses a high-frequency, electric current to kill tumor cells. Ultrasound-guided radiofrequency ablation may be effective treatment for thyroid cancer.
PURPOSE: This phase I trial is studying the side effects of radiofrequency ablation in treating patients who are undergoing surgery for thyroid cancer.
- Detailed Description
OBJECTIVES:
* Determine the frequency of complications associated with radiofrequency ablation (RFA) in patients with low-risk papillary thyroid cancer undergoing thyroidectomy.
* Determine the utility of RFA as a treatment option for these patients.
OUTLINE: This is a pilot study.
An electrosurgical probe is placed by ultrasound guidance into the center of the thyroid tumor. Patients undergo radiofrequency ablation directly to the tumor until the target temperature is reached\* for 5 minutes. Patients then undergo standard thyroidectomy.
NOTE: \*Takes approximately 15-30 minutes to reach target temperature.
After completion of study treatment, patients are followed at day 1, between days 14-21, and then periodically as deemed necessary.
PROJECTED ACCRUAL: A total of 15-40 patients will be accrued for this study.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- Not specified
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Frequency of radiofrequency ablation-associated complications at 2 weeks
- Secondary Outcome Measures
Name Time Method Amount of tumor destruction at 2 weeks
Trial Locations
- Locations (1)
UCSF Comprehensive Cancer Center
🇺🇸San Francisco, California, United States