MedPath

Radiation Therapy With or Without Bicalutamide for Recurrent pT3N0 Prostate Cancer After Radical Prostatectomy

Phase 3
Completed
Conditions
Prostate Cancer
Interventions
Drug: placebo
Radiation: radiation therapy
Registration Number
NCT00002874
Lead Sponsor
Radiation Therapy Oncology Group
Brief Summary

RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Androgens can stimulate the growth of prostate cancer cells. Hormone therapy using bicalutamide may fight prostate cancer by reducing the production of androgens. It is not yet known if radiation therapy is more effective with or without bicalutamide for prostate cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of radiation therapy with or without bicalutamide in treating patients who have stage II or stage III prostate cancer and elevated prostate-specific antigen (PSA) levels following radical prostatectomy.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
840
Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
PlaceboplaceboRadiation therapy + placebo
Bicalutamideradiation therapyRadiation therapy + bicalutamide
Placeboradiation therapyRadiation therapy + placebo
BicalutamidebicalutamideRadiation therapy + bicalutamide
Primary Outcome Measures
NameTimeMethod
Overall Survival (12-year Rates Reported)From date of randomization to 12 years.

Overall survival rates were estimated by the Kaplan-Meier method, with failure defined as death by any cause. Four-year follow-up was required of all patients, twelve-year rates are reported. Four-year follow-up was required of all patients, but twelve-year rates were reported.

Patients are followed until death.

Secondary Outcome Measures
NameTimeMethod
Second PSA Recurrence (12-year Rates Reported)From date of randomization to 12 years.

Second PSA recurrence (SPSAR) rates (i.e. first PSA failure on study) were estimated by the cumulative incidence method, with failure defined as the first occurrence of one of the following events: 1. Increase in PSA following protocol treatment according to the following criteria met during protocol treatment: If PSA dropped to undetectable level (\<0.2 ng/ml) during protocol treatment (PT) then failure = increase after PT to \>= 0.5 ng/ml ; If PSA decreased to a detectable level (≥ 0.2 ng/ml) during PT, then failure = increase PT of \>= 0.3 ng/ml above the lowest detectable level; If PSA did not decrease during PT then failure = increase in PSA after PT of \>= 0.5 ng/ml above entry PSA level. 2. The start of salvage hormone therapy. Patients alive without SPSAR at time of analysis were censored. Death without SPSAR was treated as a competing risk. Four-year follow-up was required of all patients, but twelve-year rates were reported. Patients are followed until death.

Third PSA Recurrence (12-year Rates Reported)From start of salvage hormone therapy to 12 years.

Third PSA recurrence rates (i.e. second PSA failure on study) were estimated by the cumulative incidence method, with failure defined as PSA value of 0.5ng/ml or higher or any disease progression after starting salvage hormone therapy. Patients alive without third PSA recurrence at time of analysis were censored. Death without third PSA recurrence was treated as a competing risk. Four-year follow-up was required of all patients, but twelve-year rates were reported. Patients are followed until death.

PSA Complete Response at End of Protocol TreatmentEnd of protocol treatment, which is planned to last for two years

Complete response is defined as a drop in PSA on protocol treatment to less than 0.2 ng/ml. Note that when the study opened many institutions could not detect PSA \< 05 ng/ml.

Grade 3+ ToxicityFrom date of randomization to four years.

Adverse events are graded using the Cooperative Group Common Toxicity Criteria and the Radiation Therapy Oncology Group (RTOG) Radiation Morbidity Scoring. Grade refers to severity, assigning Grades 1 through 5 based on this general guideline: Grade 0 None, Grade 1 Mild, Grade 2 Moderate, Grade 3 Severe, Grade 4 Life-threatening or disabling, Grade 5 Death related toxicity. Toxicities reported to have occurred within 90 days from the start of radiotherapy are reported as "Acute Radiotherapy", all later toxicities are reported as "Hormone therapy and late radiotherapy toxicity". The highest grade toxicity event per subject is counted within each of these time periods. Four-year follow-up was required of all patients; patients are followed until death.

Non-Prostate Cancer Death (12-year Rates Reported)From date of randomization to 12 years.

Non-prostate cancer death rates were estimated by the cumulative incidence method, with failure defined as any death that does not fall into the following categories: death due to prostate cancer or complications of protocol treatment (centrally reviewed), death with known progressive metastatic disease while on salvage hormone therapy, or death with a known rising PSA while on salvage hormone therapy. All other deaths are considered competing risks. Patients alive at time of analysis were censored. Any other death was treated as a competing risk. Four-year follow-up was required of all patients, but twelve-year rates were reported.

Patients are followed until death. "Non-Prostate cancer death" is a more accurate wording for the protocol endpoint of "non-disease-specific survival", and matches the protocol definition.

Distant Failure (12-year Rates Reported)From date of randomization to 12 years.

Distant failure rates were estimated by the cumulative incidence method, with failure defined as the first occurrence of distant failure. Patients alive without distant metastases at time of analysis were censored. Death without distant metastasis was treated as a competing risk. Four-year follow-up was required of all patients, but twelve-year rates were reported. Patients are followed until death.

Prostate Cancer Death (12-year Rates Reported)From date of randomization to 12 years.

Prostate cancer death rates were estimated by the cumulative incidence method, with failure defined as death due to prostate cancer or complications of protocol treatment (centrally reviewed), death with known progressive metastatic disease while on salvage hormone therapy, or death with a known rising PSA while on salvage hormone therapy. Patients alive at time of analysis were censored. Any other death was treated as a competing risk. Four-year follow-up was required of all patients, but twelve-year rates were reported. Patients are followed until death. "Prostate cancer death" is a more accurate wording for the protocol endpoint of "disease-specific survival", and matches the protocol definition.

Progression-free Survival (12-year Rates Reported)From date of randomization to 12 years.

Progress-free survival rates were estimated by the Kaplan-Meier method, with failure defined as the first occurrence of PSA failure, local, regional or distant failure, or death from any cause. Patients alive without progression at time of analysis were censored. Four-year follow-up was required of all patients, but twelve-year rates were reported. Patients are followed until death. "Progression-free Survival" is more accurate wording for the protocol endpoint of "Freedom from Progression", and matches the protocol definition.

Trial Locations

Locations (240)

USC/Norris Comprehensive Cancer Center and Hospital

🇺🇸

Los Angeles, California, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

🇺🇸

Baltimore, Maryland, United States

Albert Einstein Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

Toronto Sunnybrook Regional Cancer Centre

🇨🇦

Toronto, Ontario, Canada

Emory University Hospital - Atlanta

🇺🇸

Atlanta, Georgia, United States

Western Pennsylvania Hospital

🇺🇸

Pittsburgh, Pennsylvania, United States

Marlene and Stewart Greenebaum Cancer Center, University of Maryland

🇺🇸

Baltimore, Maryland, United States

Harbor Hospital Center

🇺🇸

Baltimore, Maryland, United States

Northwestern Memorial Hospital

🇺🇸

Chicago, Illinois, United States

Ireland Cancer Center

🇺🇸

Cleveland, Ohio, United States

Cleveland Clinic Taussig Cancer Center

🇺🇸

Cleveland, Ohio, United States

Dana-Farber Cancer Institute

🇺🇸

Boston, Massachusetts, United States

CCOP - Southern Nevada Cancer Research Foundation

🇺🇸

Las Vegas, Nevada, United States

Veterans Affairs Medical Center - Miami

🇺🇸

Miami, Florida, United States

Sylvester Cancer Center, University of Miami

🇺🇸

Miami, Florida, United States

Baptist Hospital of Miami

🇺🇸

Miami, Florida, United States

Clarian Health Partners Inc.

🇺🇸

Indianapolis, Indiana, United States

Regional Cancer Center

🇺🇸

Indianapolis, Indiana, United States

Dixie Regional Medical Center

🇺🇸

Saint George, Utah, United States

McGill University

🇨🇦

Montreal, Quebec, Canada

California Cancer Center

🇺🇸

Fresno, California, United States

Loma Linda University Medical Center

🇺🇸

Loma Linda, California, United States

Cancer Care Center

🇺🇸

Pomona, California, United States

New York Methodist Hospital

🇺🇸

Brooklyn, New York, United States

Barrett Cancer Center

🇺🇸

Cincinnati, Ohio, United States

UCSF Cancer Center and Cancer Research Institute

🇺🇸

San Francisco, California, United States

Vanderbilt-Ingram Cancer Center

🇺🇸

Nashville, Tennessee, United States

Latter Day Saints Hospital

🇺🇸

Salt Lake City, Utah, United States

University of Utah Health Sciences Center

🇺🇸

Salt Lake City, Utah, United States

Newark Beth Israel Medical Center

🇺🇸

Newark, New Jersey, United States

Foundation for Cancer Research and Education

🇺🇸

Phoenix, Arizona, United States

St. Anthony Hospital

🇺🇸

Oklahoma City, Oklahoma, United States

University of Oklahoma Health Sciences Center

🇺🇸

Oklahoma City, Oklahoma, United States

University of Alabama at Birmingham Comprehensive Cancer Center

🇺🇸

Birmingham, Alabama, United States

Henry Ford Hospital

🇺🇸

Detroit, Michigan, United States

CCOP - Columbia River Program

🇺🇸

Portland, Oregon, United States

Mayo Clinic Cancer Center

🇺🇸

Rochester, Minnesota, United States

Northwestern Ontario Regional Cancer Centre, Thunder Bay

🇨🇦

Thunder Bay, Ontario, Canada

H. Lee Moffitt Cancer Center and Research Institute

🇺🇸

Tampa, Florida, United States

CCOP - Missouri Valley Cancer Consortium

🇺🇸

Omaha, Nebraska, United States

Nebraska Health System

🇺🇸

Omaha, Nebraska, United States

Methodist Cancer Center - Omaha

🇺🇸

Omaha, Nebraska, United States

St. Luke's Medical Center

🇺🇸

Milwaukee, Wisconsin, United States

Medical College of Wisconsin

🇺🇸

Milwaukee, Wisconsin, United States

Veterans Affairs Medical Center - Milwaukee (Zablocki)

🇺🇸

Milwaukee, Wisconsin, United States

Barbara Ann Karmanos Cancer Institute

🇺🇸

Detroit, Michigan, United States

CCOP - Ann Arbor Regional

🇺🇸

Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center

🇺🇸

Ann Arbor, Michigan, United States

CCOP - Southeast Cancer Control Consortium

🇺🇸

Winston-Salem, North Carolina, United States

Comprehensive Cancer Center at Wake Forest University

🇺🇸

Winston-Salem, North Carolina, United States

Comprehensive Cancer Institute of Huntsville

🇺🇸

Huntsville, Alabama, United States

Huntsville Hospital System

🇺🇸

Huntsville, Alabama, United States

MBCCOP - Gulf Coast

🇺🇸

Mobile, Alabama, United States

Alabama Oncology, LLC

🇺🇸

Montgomery, Alabama, United States

Radiation Oncology Associates of West Alabama

🇺🇸

Tuscaloosa, Alabama, United States

City of Hope Comprehensive Cancer Center

🇺🇸

Duarte, California, United States

Saint Agnes Cancer Center

🇺🇸

Fresno, California, United States

Sutter Health West Cancer Research Group

🇺🇸

Greenbrae, California, United States

CCOP - Bay Area Tumor Institute

🇺🇸

Oakland, California, United States

Jonsson Comprehensive Cancer Center, UCLA

🇺🇸

Los Angeles, California, United States

Veterans Affairs Medical Center - Long Beach

🇺🇸

Long Beach, California, United States

Huntington Cancer Center

🇺🇸

Pasadena, California, United States

Radiation Oncology Center - Sacramento

🇺🇸

Sacramento, California, United States

Radiation Medical Group, Inc.

🇺🇸

San Diego, California, United States

O'Connor Hospital

🇺🇸

San Jose, California, United States

CCOP - Santa Rosa Memorial Hospital

🇺🇸

Santa Rosa, California, United States

Memorial Hospital Cancer Center

🇺🇸

Colorado Springs, Colorado, United States

David Grant Medical Center

🇺🇸

Travis Air Force Base, California, United States

CCOP - Christiana Care Health Services

🇺🇸

Wilmington, Delaware, United States

Saint Mary's Hospital and Medical Center

🇺🇸

Grand Junction, Colorado, United States

University of Colorado Cancer Center

🇺🇸

Denver, Colorado, United States

Florida Radiation Oncology Group

🇺🇸

Jacksonville, Florida, United States

Health First Holmes Regional Medical Center

🇺🇸

Melbourne, Florida, United States

CCOP - Mount Sinai Medical Center

🇺🇸

Miami Beach, Florida, United States

Bay Medical Center

🇺🇸

Panama City, Florida, United States

Gulf Coast Cancer Treatment Center

🇺🇸

Panama City, Florida, United States

Tallahassee Memorial Healthcare

🇺🇸

Tallahassee, Florida, United States

CCOP - Atlanta Regional

🇺🇸

Atlanta, Georgia, United States

Regional Radiation Oncology Center at Rome

🇺🇸

Rome, Georgia, United States

Northwest Community Hospital

🇺🇸

Arlington Heights, Illinois, United States

Medical Center/John B. Amos Community Cancer Center

🇺🇸

Columbus, Georgia, United States

Ingalls Memorial Hospital

🇺🇸

Harvey, Illinois, United States

Methodist Medical Center of Illinois

🇺🇸

Peoria, Illinois, United States

Lutheran General Cancer Care Center

🇺🇸

Park Ridge, Illinois, United States

Bloomington Hospital

🇺🇸

Bloomington, Indiana, United States

Veterans Affairs Medical Center - Indianapolis (Roudebush)

🇺🇸

Indianapolis, Indiana, United States

St. John's Medical Center

🇺🇸

Anderson, Indiana, United States

CCOP - Northern Indiana CR Consortium

🇺🇸

South Bend, Indiana, United States

Ball Memorial Hospital

🇺🇸

Muncie, Indiana, United States

Wendt Regional Cancer Center of Finley Hospital

🇺🇸

Dubuque, Iowa, United States

Merle M. Mahr Cancer Center

🇺🇸

Madisonville, Kentucky, United States

Mary Bird Perkins Cancer Center

🇺🇸

Baton Rouge, Louisiana, United States

Maine Medical Center

🇺🇸

Portland, Maine, United States

Greater Baltimore Medical Center and Cancer Center

🇺🇸

Baltimore, Maryland, United States

Anne Arundel Oncology Center

🇺🇸

Annapolis, Maryland, United States

Sinai Hospital of Baltimore

🇺🇸

Baltimore, Maryland, United States

Peninsula Regional Medical Center

🇺🇸

Salisbury, Maryland, United States

Massachusetts General Hospital Cancer Center

🇺🇸

Boston, Massachusetts, United States

Cape Cod Hospital

🇺🇸

Hyannis, Massachusetts, United States

Veterans Affairs Medical Center - Boston (Jamaica Plain)

🇺🇸

Jamaica Plain, Massachusetts, United States

McLaren Regional Cancer Center

🇺🇸

Flint, Michigan, United States

MidMichigan Medical Center - Midland

🇺🇸

Midland, Michigan, United States

William Beaumont Hospital - Troy

🇺🇸

Troy, Michigan, United States

Marquette General Hospital

🇺🇸

Marquette, Michigan, United States

CCOP - Beaumont

🇺🇸

Royal Oak, Michigan, United States

CCOP - Metro-Minnesota

🇺🇸

Saint Louis Park, Minnesota, United States

Mallinckrodt Institute of Radiology

🇺🇸

Saint Louis, Missouri, United States

St. Louis University Health Sciences Center

🇺🇸

Saint Louis, Missouri, United States

Cancer Research for the Ozarks

🇺🇸

Springfield, Missouri, United States

CCOP - Cancer Research for the Ozarks

🇺🇸

Springfield, Missouri, United States

Elliot Regional Cancer Center

🇺🇸

Manchester, New Hampshire, United States

Norris Cotton Cancer Center

🇺🇸

Lebanon, New Hampshire, United States

CCOP - Montana Cancer Consortium

🇺🇸

Billings, Montana, United States

Cooper Cancer Institute

🇺🇸

Camden, New Jersey, United States

Veterans Affairs Medical Center - East Orange

🇺🇸

East Orange, New Jersey, United States

Trinitas Hospital - Jersey Street Campus

🇺🇸

Elizabeth, New Jersey, United States

South Jersey Regional Cancer Center

🇺🇸

Millville, New Jersey, United States

Cancer Institute of New Jersey

🇺🇸

New Brunswick, New Jersey, United States

John F. Kennedy Medical Center

🇺🇸

Edison, New Jersey, United States

Monmouth Medical Center

🇺🇸

Long Branch, New Jersey, United States

Fox Chase Cancer Center at Virtua Memorial Hospital Burlington County

🇺🇸

Mount Holly, New Jersey, United States

Community Medical Center

🇺🇸

Toms River, New Jersey, United States

Somerset Medical Center

🇺🇸

Somerville, New Jersey, United States

St. Francis Medical Center

🇺🇸

Trenton, New Jersey, United States

Capital Health System at Mercer

🇺🇸

Trenton, New Jersey, United States

Cancer Center of Albany Medical Center

🇺🇸

Albany, New York, United States

Radiation Oncology Associates of Albuquerque

🇺🇸

Albuquerque, New Mexico, United States

Associated Radiologists, P.A.

🇺🇸

Warren, New Jersey, United States

State University of New York Health Science Center at Brooklyn

🇺🇸

Brooklyn, New York, United States

Roswell Park Cancer Institute

🇺🇸

Buffalo, New York, United States

Finger Lakes Radiation Oncology Center

🇺🇸

Clifton Springs, New York, United States

Champlain Valley Physicians Hospital Medical Center

🇺🇸

Plattsburgh, New York, United States

CCOP - North Shore University Hospital

🇺🇸

Manhasset, New York, United States

Herbert Irving Comprehensive Cancer Center

🇺🇸

New York, New York, United States

Vassar Brothers Medical Center

🇺🇸

Poughkeepsie, New York, United States

James P. Wilmot Cancer Center

🇺🇸

Rochester, New York, United States

Riverhill Radiation Oncology

🇺🇸

Yonkers, New York, United States

Northeast Medical Center

🇺🇸

Concord, North Carolina, United States

East Carolina University School of Medicine

🇺🇸

Greenville, North Carolina, United States

Christ Hospital

🇺🇸

Cincinnati, Ohio, United States

Akron General Medical Center

🇺🇸

Akron, Ohio, United States

Trinity Cancer Care Center

🇺🇸

Minot, North Dakota, United States

CCOP - Columbus

🇺🇸

Columbus, Ohio, United States

Arthur G. James Cancer Hospital - Ohio State University

🇺🇸

Columbus, Ohio, United States

CCOP - Dayton

🇺🇸

Kettering, Ohio, United States

CCOP - Oklahoma

🇺🇸

Tulsa, Oklahoma, United States

Lehigh Valley Hospital

🇺🇸

Allentown, Pennsylvania, United States

St. Luke's Hospital Cancer Center

🇺🇸

Bethlehem, Pennsylvania, United States

Geisinger Medical Center

🇺🇸

Danville, Pennsylvania, United States

Delaware County Memorial Hospital

🇺🇸

Drexel Hill, Pennsylvania, United States

Mercy Fitzgerald Hospital

🇺🇸

Darby, Pennsylvania, United States

Veterans Affairs Medical Center - Philadelphia

🇺🇸

Philadelphia, Pennsylvania, United States

University of Pennsylvania Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

Pocono Cancer Center

🇺🇸

East Stroudsburg, Pennsylvania, United States

Kimmel Cancer Center of Thomas Jefferson University - Philadelphia

🇺🇸

Philadelphia, Pennsylvania, United States

Milton S. Hershey Medical Center

🇺🇸

Hershey, Pennsylvania, United States

Fox Chase Cancer Center

🇺🇸

Philadelphia, Pennsylvania, United States

University of Pittsburgh Cancer Institute

🇺🇸

Pittsburgh, Pennsylvania, United States

Reading Hospital and Medical Center

🇺🇸

Reading, Pennsylvania, United States

Mercy Hospital of Pittsburgh

🇺🇸

Pittsburgh, Pennsylvania, United States

Roger Williams Medical Center/BUSM

🇺🇸

Providence, Rhode Island, United States

Wilkes Barre General Hospital

🇺🇸

Wilkes-Barre, Pennsylvania, United States

Mercy Hospital Cancer Center - Scranton

🇺🇸

Scranton, Pennsylvania, United States

CCOP - Greenville

🇺🇸

Greenville, South Carolina, United States

Rapid City Regional Hospital

🇺🇸

Rapid City, South Dakota, United States

University of Tennessee Cancer Institute

🇺🇸

Memphis, Tennessee, United States

Jackson-Madison County General Hospital

🇺🇸

Jackson, Tennessee, United States

Harrington Cancer Center

🇺🇸

Amarillo, Texas, United States

University of Texas Medical Branch

🇺🇸

Galveston, Texas, United States

University of Texas - MD Anderson Cancer Center

🇺🇸

Houston, Texas, United States

Wilford Hall Medical Center

🇺🇸

Lackland Air Force Base, Texas, United States

Joe Arrington Cancer Research and Treatment Center

🇺🇸

Lubbock, Texas, United States

Bayshore Medical Center

🇺🇸

Pasadena, Texas, United States

Green Mountain Oncology Group

🇺🇸

Bennington, Vermont, United States

Vermont Cancer Center

🇺🇸

Burlington, Vermont, United States

Cancer Center at the University of Virginia

🇺🇸

Charlottesville, Virginia, United States

RMH Regional Cancer Center

🇺🇸

Harrisonburg, Virginia, United States

Naval Medical Center, Portsmouth

🇺🇸

Portsmouth, Virginia, United States

Virginia Mason Medical Center

🇺🇸

Seattle, Washington, United States

Yakima Valley Memorial Hospital

🇺🇸

Yakima, Washington, United States

Deaconess Medical Center

🇺🇸

Spokane, Washington, United States

St. Vincent Hospital

🇺🇸

Green Bay, Wisconsin, United States

CCOP - St. Vincent Hospital Cancer Center, Green Bay

🇺🇸

Green Bay, Wisconsin, United States

Gundersen Lutheran Medical Foundation

🇺🇸

La Crosse, Wisconsin, United States

Schiffler Cancer Center

🇺🇸

Wheeling, West Virginia, United States

Community Memorial Hospital

🇺🇸

Menomonee Falls, Wisconsin, United States

Columbia Hospital

🇺🇸

Milwaukee, Wisconsin, United States

Marshfield Clinic

🇺🇸

Marshfield, Wisconsin, United States

Waukesha Memorial Hospital

🇺🇸

Waukesha, Wisconsin, United States

Cross Cancer Institute

🇨🇦

Edmonton, Alberta, Canada

All Saints Cancer Center

🇺🇸

Racine, Wisconsin, United States

Cancer Care Ontario-London Regional Cancer Centre

🇨🇦

London, Ontario, Canada

Tom Baker Cancer Center - Calgary

🇨🇦

Calgary, Alberta, Canada

Nova Scotia Cancer Centre

🇨🇦

Halifax, Nova Scotia, Canada

Newfoundland Cancer Treatment and Research Foundation

🇨🇦

St. Johns, Newfoundland and Labrador, Canada

Cancer Care Ontario-Hamilton Regional Cancer Centre

🇨🇦

Hamilton, Ontario, Canada

Kingston Regional Cancer Centre

🇨🇦

Kingston, Ontario, Canada

Northeastern Ontario Regional Cancer Centre, Sudbury

🇨🇦

Sudbury, Ontario, Canada

Ottawa Regional Cancer Centre

🇨🇦

Ottawa, Ontario, Canada

CHUS-Hopital Fleurimont

🇨🇦

Fleurimont, Quebec, Canada

Princess Margaret Hospital

🇨🇦

Toronto, Ontario, Canada

Centre Hospitalier de l'Universite de Montreal

🇨🇦

Montreal, Quebec, Canada

Centre Hospitalier Universitaire de Quebec

🇨🇦

Quebec City, Quebec, Canada

Saskatoon Cancer Centre

🇨🇦

Saskatoon, Saskatchewan, Canada

Allan Blair Cancer Centre

🇨🇦

Regina, Saskatchewan, Canada

University Hospitals of Cleveland

🇺🇸

Cleveland, Ohio, United States

CCOP - Central Illinois

🇺🇸

Decatur, Illinois, United States

Hurley Medical Center

🇺🇸

Flint, Michigan, United States

William Beaumont Hospital

🇺🇸

Royal Oak, Michigan, United States

Sarasota Radiation and Medical Oncology Center

🇺🇸

Sarasota, Florida, United States

CCOP - Upstate Carolina

🇺🇸

Spartanburg, South Carolina, United States

CCOP - Kalamazoo

🇺🇸

Kalamazoo, Michigan, United States

Ellis Fischel Cancer Center - Columbia

🇺🇸

Columbia, Missouri, United States

Akron City Hospital

🇺🇸

Akron, Ohio, United States

CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C.

🇺🇸

Syracuse, New York, United States

Loyola University Medical Center

🇺🇸

Maywood, Illinois, United States

Mount Diablo Medical Center

🇺🇸

Concord, California, United States

Valley Hospital

🇺🇸

Ridgewood, New Jersey, United States

Saint John Regional Hospital

🇨🇦

Saint John, New Brunswick, Canada

Atlantic City Medical Center

🇺🇸

Pomona, New Jersey, United States

St. John Health System

🇺🇸

Tulsa, Oklahoma, United States

York Hospital

🇺🇸

York, Pennsylvania, United States

Hospital of St. Raphael

🇺🇸

New Haven, Connecticut, United States

James Graham Brown Cancer Center

🇺🇸

Louisville, Kentucky, United States

Louisville Radiation Oncology

🇺🇸

Louisville, Kentucky, United States

MD Anderson Cancer Center Orlando

🇺🇸

Orlando, Florida, United States

CCOP - Kansas City

🇺🇸

Kansas City, Missouri, United States

Lineberger Comprehensive Cancer Center, UNC

🇺🇸

Chapel Hill, North Carolina, United States

University of Florida Health Science Center

🇺🇸

Gainesville, Florida, United States

MBCCOP - Hawaii

🇺🇸

Honolulu, Hawaii, United States

Central Baptist Hospital

🇺🇸

Lexington, Kentucky, United States

Albert B. Chandler Medical Center, University of Kentucky

🇺🇸

Lexington, Kentucky, United States

Tulane University School of Medicine

🇺🇸

New Orleans, Louisiana, United States

Cancer Center at Lexington Clinic

🇺🇸

Lexington, Kentucky, United States

MBCCOP - LSU Health Sciences Center

🇺🇸

New Orleans, Louisiana, United States

CCOP - Ochsner

🇺🇸

New Orleans, Louisiana, United States

Bon-Secours - St. Mary's Hospital

🇺🇸

Richmond, Virginia, United States

Massey Cancer Center

🇺🇸

Richmond, Virginia, United States

Southern Wisconsin Radiotherapy Center

🇺🇸

Madison, Wisconsin, United States

University of Wisconsin Comprehensive Cancer Center

🇺🇸

Madison, Wisconsin, United States

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