Influence of renal function on the circadian variation of cardiac troponi

Completed

• Conditions: Chronic Kidney Disease; impaired renal function; 10011082; 10038430

• Registration Number: NL-OMON41818
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2016-01-13
• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Individuals (age >18 years) with chronic kidney disease (CKD) stage 3 (eGFR 30*59 mL/min/1.73m2) and stage 4 (eGFR 15*29 mL/min/1.73m2) without dialysis and with no evidence of active cardiac disease (abscence of: angina pectoris, cardiomyopathy and myocarditis) (age >18 years) will be recruited to participate in our study.

Exclusion Criteria

- acute myocardial infarction (AMI) in the last year.
- anaemia (Hb < 6.5 mmol/L)
- pulmonary embolism in the last six months

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Concentrations of cardiac troponin T and I over 24 hours, after one week, after<br /><br>one month and after three months</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Measures of:<br /><br>* Basic clinical chemistry parameters to verify a non-disturbed day-night<br /><br>rhythm; such as cortisol, creatine kinase and electrolyte concentrations<br /><br>* Basic clinical chemistry, haematological and endocrinological parameters to<br /><br>assess the variation of these parameters in subjects with diminished kidney<br /><br>function<br /><br>* 24 hour automatic blood pressure measurements<br /><br>* Albumin concentration and hematocrit values, to correct for hydration status.<br /><br>* Concentration of creatinine, to estimate the glomerular filtration rate.<br /><br>* Urine concentrations of creatinine, electrolytes and cardiac markers.</p><br>