Characteristics of SARS-CoV-2 Reinfection
- Conditions
- COVID-19
- Registration Number
- NCT05748262
- Lead Sponsor
- Jiming Zhang
- Brief Summary
As the COVID-19 pandemic continues and the number of individuals with previous infection rises, numbers of SARS-CoV-2 reinfection are increasing. The second Omicron wave in Shanghai, China caused by BA.5-sublineages led to a large fraction of reinfections among BA.2 primary infections. To better understand the SARS-CoV-2 reinfection rate and clinical severity of reinfections, the investigators conducted a multi-centre cohort study. The investigators hope to provide valuable clinical evidences for reinfections and offer guidance for future policy making.
- Detailed Description
The investigators used data from Huashan Hospital, Renji Hospital, and Shanghai Jing' an Central Hospital to collect information on SARS-CoV-2 primary infections with BA.2 during 1 March to 23 May 2022, and followed up for participants' reinfections with BA.5-lineages during 1 December 2022 to 14 January 2023. After matched 1:1 by age and gender with the reinfection cohort, data of primary infections with BA.5-sublineages were also collected. Reinfection cases were defined as having positive COVID-19 PCR or antigen test, at least 90 days after participants' first positive testing. Basic information, vaccination status, time interval between two infections, and clinical manifestations were collected.
Recruitment & Eligibility
- Status
- ENROLLING_BY_INVITATION
- Sex
- All
- Target Recruitment
- 1144
- All PCR- or RAT-confirmed SARS-CoV-2 reinfections were included in the study.
- Patients who did not know if they were reinfected were excluded.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Characteristics of all enrolled SARS-CoV-2 patients during two periods. 2022-12~2023-2 Basic information, vaccination status, time interval between two infections, and clinical manifestations
Characteristics and multivariate analysis of risk factors for SARS-CoV-2 reinfection by gender, age, vaccination status, clinical severity and Ct values of primary infection. 2022-12~2023-2 Sex, age, vaccination status, clinical severity of primary infection, and Ct values during primary infection
Clinical characteristics of SARS-CoV-2 primary infection and reinfection among patients with reinfection in Shanghai 2022-12~2023-2 Fever, fatigue, sore throat, cough, anosmia and/or ageusia, muscle and/or joint pain, headache, chest congestion, diarrhea, runny nose, sleeping disorders, and pneumonia
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Huashan Hospital Affiliated to Fudan University
🇨🇳Shanghai, China