A research cum intervention multi-centric study to strengthen National TB Elimination Programme (NTEP)

Not yet recruiting

Conditions: Tuberculosis,

Registration Number: CTRI/2023/06/053750

Lead Sponsor: Indian Council of Medical Research

Brief Summary: Tuberculosis, one of the deadliest infectious diseases poses a major threat to public health. According to WHO 2020 Global TB report, annually 10 million new TB cases are reported, with estimated 1.5 million deaths due to TB (Harding, 2020, Global TB Report, 2020). India accounts for a staggering 27% of the global TB burden (Harding, 2020). This calls for an urgent need to focus on hastening the efforts and to adopt aggressive strategies to eradicate this *Mycobacterium*. India envisions elimination of tuberculosis by the year 2025 (Global TB Report, 2020). This project aims to develop a novel comprehensive model to address these challenges and demonstrate the impact of these strategies in reducing the TB incidence in the vulnerable communities/areas/settings with high burden of the disease, to achieve TB elimination target of 2025. In this project we would like to address common challenges existing in various communities/areas/settings which include Stigma, community practices that are hard to remove in-spite of counseling, health system challenges, access to health care etc, which hamper proper implementation of the national programme guidelines. New challenges that may be encountered while implementing the NTEP strategies, will be addressed in a structered manner through novel approaches, diagnosing all new cases in the defined select area at the earliest using community camps. Working closely with state TB department and with proper and early initiation of the treatment of cases and preventive therapy of the contacts and vulnerable population in the community, this project aims to break the transmission chain and achieve 60-80% reduction in incidence of TB using cost effective novel model.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 100000

Inclusion Criteria

Efforts will be made to include all cases as defined below: -Participants (symptomatics/TB suspects) of all age groups and of both genders -Contacts of TB patients on treatment since last 6 months (from Nikshay) -All symptomatics and contacts of TB index cases Confirmed TB cases that have not yet started TB treatment and newly diagnosed patients and not having started treatment,are also eligible for the TB elimination programme -All patients who have been detected for any TB (EPTB) within 6 months will be included -All contacts of TB index cases including House Hold Contact(HHC) for screening and diagnosis of any TB.

Exclusion Criteria

All cases other than inclusion criteria, are excluded.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Site specific additional gaps, barriers and challenges in implementation of NTEP activities in the selected district/area will be identified and other novel interventional strategies based on newly identified challenges will be developed and implemented in community to strengthen NTEP and novel case finding, treatment, adherence and preventive strategies at local level will be implemented.	24 Months

Secondary Outcome Measures

Name	Time	Method
Reasons for perceived and enacted social stigma for TB in selected communities will be assessed and interventional strategies based in the novel identified gaps, barriers and challenges as per the community settings including migratory population will be developed.	24 Months

Trial Locations

Locations (7): Aizawl Municipal Council
🇮🇳
Aizawl, MIZORAM, India
Ambegaon and Junnar
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Pune, MAHARASHTRA, India
Bangalore
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Bangalore, KARNATAKA, India
Kingsway Camp
🇮🇳
Delhi, DELHI, India
Ratlam
🇮🇳
Ratlam, MADHYA PRADESH, India
Urban slums of Bhubaneswar
🇮🇳
Khordha, ORISSA, India
Ziro Valley
🇮🇳
Subansiri, ARUNACHAL PRADESH, India
Aizawl Municipal Council
🇮🇳Aizawl, MIZORAM, India
Dr Khwairakpam Premjit Singh
Principal investigator
8132089197
premjituno@gmail.com