Etoricoxib Versus Gabapentin for Knee Arthroscopy
- Conditions
- Knee Arthroscopy
- Interventions
- Drug: Gabapentin, Etoricoxib, Sugar pill
- Registration Number
- NCT00799149
- Lead Sponsor
- Meir Medical Center
- Brief Summary
To determine that when administered as part of a multimodal analgesic regimen, use of the new COX-2 antagonist etoricoxib (120 mg/day, per os) is more effective in improving postoperative pain management after knee arthroscopy than gabapentin (1.2 g/day, per os).
- Detailed Description
Background: Post-discharge pain remains a significant problem after many ambulatory surgery procedures. Both etoricoxib and gabapentin have been used to prevent postoperative pain; however their relative efficacy in the post-discharge period is not known. We hypothesized that daily use of etoricoxib would offer advantages over gabapentin as part of a multimodal analgesic regimen in the perioperative period due to its pharmacokinetic profile.
Methods: Seventy-five healthy outpatients undergoing elective ambulatory knee arthroscopy were randomly assigned to receive identical-appearing capsules containing either a placebo, gabapentin (1.2g, or etoricoxib 120 mg, 30-90 min before skin incision and at 08H00 on the first, second, and third postoperative days. Post-discharge pain was treated with "rescue" dipyrone syrup (500 mg). Pain intensity (as assessed using a 100 visual analog scale), dipyrone usage, and the incidence of nausea and vomiting, sedation and anxiety were recorded at specific time intervals in the postoperative period. The recovery of functional activity was assessed at 96 h after surgery using a validated questionnaire.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 75
- Elective ambulatory knee arthroscopy
- History of clinically-significant cardiovascular,pulmonary,hepatic,renal, neurologic, psychiatric or metabolic disease
- Patients chronically receiving pain killers
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Gabapentin Gabapentin, Etoricoxib, Sugar pill Gabapentin (1200 mg) administered 30-90 min before the patient entered the operating room; Subsequent doses of Gabapentin (1200 mg)were administered on the mornings (08H00) of the first, second, and third postoperative days. Etoricoxib Gabapentin, Etoricoxib, Sugar pill Etoricoxib (120 mg)administered 30-90 min before the patient entered the operating room; Subsequent doses of etoricoxib (120 mg)were administered on the mornings (08H00) of the first, second, and third postoperative days. Sugar pill Gabapentin, Etoricoxib, Sugar pill Sugar pill administered 30-90 min before the patient entered the operating room. Subsequent doses of Sugar pill were administered on the mornings (08H00) of the first, second, and third postoperative days.
- Primary Outcome Measures
Name Time Method 1)Pain intensity (as assessed using a 100 visual analog scale) 2)Incidence of dipyrone usage 96 hours post-operation
- Secondary Outcome Measures
Name Time Method The recovery of functional activity 96 hours
Trial Locations
- Locations (1)
Meir Medical Center
🇮🇱Kfar-Saba, Israel