Analysis of the correlation of serum-biomarker based measures of neurodegeneration and synaptic dysfunction with outcome in patients with delirium and acute encephalopathy

Recruiting

• Conditions: F05.0; F05.1; F05.8; F05.9; Delirium not superimposed on dementia, so described; Delirium superimposed on dementia; Other delirium; Delirium, unspecified

• Registration Number: DRKS00027078
• Lead Sponsor: Institut für Klinische Chemie, Haus U30und Klinik für Neurologie, Haus DUniverstitätsklinikum Schleswig-Holstein

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-11-08
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

Delirium: Age >= 18 years, Patient or legal representative gave consent, clinical diagnosis of delirium or acute encephalopathy, screened by CAM-ICU and validated by ICD-10 criteria

Controls: Age >= 18 years, Patient or legal representative gave consent

Exclusion Criteria

Documented history of dementia, history of intracranial and cardiovascular surgery or recent interfering neurological events within the past year, including stroke, trauma, encephalitis, brain metastasis and seizures

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in biomarker levels of neurodegenerative and synaptic biomarkers in asservated plasma between patients with delirium and without delirium.

Secondary Outcome Measures

Name	Time	Method
Correlations of biomarker levels with demographic (e.g., age, sex) and diagnostic (e.g., laboratory values, cause of delirium) parameters.