rTMS/CBT compared to antidepressant treatment
Not Applicable
Completed
- Conditions
- <p>Major depressive disorder</p>10012375
- Registration Number
- NL-OMON24799
- Lead Sponsor
- ZonMw
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 90
Inclusion Criteria
>18 years of age. Failed response to 2 adequate dose-duration trials with antidepressants. Current episode of less than two years. Moderate or severe depression (HDRS-17 > 16) without psychotic features.
Exclusion Criteria
Lifetime diagnosis of bipolar disorder, schizophrenia or schizoaffective disorder, current substance abuse disorder, or organic brain syndrome. Presence of a concurrent significant medical condition impeding the ability to participate. Previous treatment with rTMS. Epilepsy, convulsion or seizure. Serious head trauma or brain surgery. Large or ferromagnetic metal parts in the head (except for a dental wire) Implanted cardiac pacemaker or neurostimulator. Pregnancy. Previous treatment with ECT.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Score on the Hamilton Depression Rating Scale (HDRS-17)</p><br>
- Secondary Outcome Measures
Name Time Method <p>Remission (cost-effectiveness) Quality adjusted life years</p><br>